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A critical component of reproduction is the luteinising hormone (<jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>) surge, which is mediated by oestradiol (E<jats:sub>2<\/jats:sub>) and neuroprogesterone interacting to stimulate kisspeptin release in the rostral periventricular nucleus of the third ventricle in rats. Recent evidence indicates the involvement of both classical and membrane E<jats:sub>2<\/jats:sub> and progesterone signalling in this pathway. A metabolite of gonadotrophin\u2010releasing hormone (Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>), Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>\u2010(1\u20105), has been shown to stimulate Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> expression and secretion, and has a role in the regulation of lordosis. Additionally, gonadotrophin release\u2010inhibitory hormone (Gn<jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>) projects to and influences the activity of Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> neurones in birds. Stress\u2010induced changes in Gn<jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> have been shown to alter breeding behaviour in birds, demonstrating another mechanism for the molecular control of reproduction. Peripherally, paracrine and autocrine actions within the gonad have been suggested as therapeutic targets for infertility in both males and females. Dysfunction of testicular prostaglandin synthesis is a possible cause of idiopathic male infertility. Indeed, local production of melatonin and corticotrophin\u2010releasing hormone could influence spermatogenesis via immune pathways in the gonad. In females, vascular endothelial growth factor A has been implicated in an angiogenic process that mediates development of the corpus luteum and thus fertility via the Notch signalling pathway. Age\u2010induced decreases in fertility involve ovarian kisspeptin and its regulation of ovarian sympathetic innervation. Finally, morphological changes in the arcuate nucleus of the hypothalamus influence female sexual receptivity in rats. The processes mediating these morphological changes have been shown to involve the rapid effects of E<jats:sub>2<\/jats:sub> controlling synaptogenesis in this hypothalamic nucleus. In summary, this review highlights new research in these areas, focusing on recent findings concerning the molecular mechanisms involved in the central and peripheral hormonal control of reproduction.<\/jats:p>","DOI":"10.1111\/jne.12405","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T21:47:05Z","timestamp":1466632025000},"source":"Crossref","is-referenced-by-count":34,"title":["Peripheral and Central Mechanisms Involved in the Hormonal Control of Male and Female Reproduction"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4798-2457","authenticated-orcid":false,"given":"L. M.","family":"Rudolph","sequence":"first","affiliation":[{"name":"Department of Neurobiology, Laboratory of Neuroendocrinology David Geffen School of Medicine at UCLA Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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