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These changes are reverted by treatment with 17\u03b2\u2010oestradiol. To determine which oestradiol receptor (<jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>) type is involved in these neuroprotective effects, we used agonists of the <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u03b1 [propylpyrazole triol (<jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content>)] and the <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u03b2 [diarylpropionitrite (<jats:styled-content style=\"fixed-case\">DPN<\/jats:styled-content>)] given over 2\u00a0weeks to 4\u2010month\u2010old male <jats:styled-content style=\"fixed-case\">SHR<\/jats:styled-content>. Wistar Kyoto normotensive rats served as controls. Using immunocytochemistry, we determined glial fibrillary protein (GFAP)+ astrocytes in the <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>1, <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>3 and hilus of the dentate gyrus of the hippocampus, aromatase immunostaining in the hilus, and doublecortin (<jats:styled-content style=\"fixed-case\">DCX<\/jats:styled-content>)+ neuronal progenitors in the inner granular zone of the dentate gyrus. Brain\u2010derived neurotrophic factor <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> was also measured in the hippocampus by the quantitative polymerase chain reaction. In SHR, <jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content> had no effect on blood pressure, decreased astrogliosis, slightly increased <jats:styled-content style=\"fixed-case\">BDNF mRNA<\/jats:styled-content>, had no effect on the number of <jats:styled-content style=\"fixed-case\">DCX<\/jats:styled-content>+ progenitors, and increased aromatase staining. Treatment with <jats:styled-content style=\"fixed-case\">DPN<\/jats:styled-content> decreased blood pressure, decreased astrogliosis, increased <jats:styled-content style=\"fixed-case\">BDNF mRNA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DCX<\/jats:styled-content>+ progenitors, and did not modify aromatase staining. We hypothesise that, although both receptor types may participate in the previously reported beneficial effects of 17\u03b2\u2010oestradiol in <jats:styled-content style=\"fixed-case\">SHR<\/jats:styled-content>, receptor activation with <jats:styled-content style=\"fixed-case\">DPN<\/jats:styled-content> may preferentially facilitate <jats:styled-content style=\"fixed-case\">BDNF mRNA<\/jats:styled-content> expression and neurogenesis. The results of the present study may help in the design of <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u2010based neuroprotection for the encephalopathy of hypertension.<\/jats:p>","DOI":"10.1111\/jne.12415","type":"journal-article","created":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T14:46:08Z","timestamp":1471013168000},"source":"Crossref","is-referenced-by-count":18,"title":["Selective Oestrogen Receptor Agonists Rescued Hippocampus Parameters in Male Spontaneously Hypertensive Rats"],"prefix":"10.1111","volume":"28","author":[{"given":"L.","family":"Pietranera","sequence":"first","affiliation":[{"name":"Laboratory of Neuroendocrine Biochemistry Instituto de Biolog\u00eda y Medicina Experimental Buenos Aires Argentina"},{"name":"Department of Human Biochemistry Faculty of Medicine University of Buenos Aires Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Correa","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroendocrine Biochemistry Instituto de Biolog\u00eda y Medicina Experimental Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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