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The intact <jats:styled-content style=\"fixed-case\">RLN<\/jats:styled-content>3\u2010injected rats displayed a higher body weight than the vehicle\u2010treated groups, and this increase was statistically significantly stronger in female rats compared to male rats. In addition, feed efficiency and gonadal white adipose tissue weight were higher in female <jats:styled-content style=\"fixed-case\">RLN<\/jats:styled-content>3\u2010injected rats. Chronic i.c.v. administration of <jats:styled-content style=\"fixed-case\">RLN<\/jats:styled-content>3 activated the <jats:styled-content style=\"fixed-case\">HPG<\/jats:styled-content> axis in intact male rats, whereas inhibition of the <jats:styled-content style=\"fixed-case\">HPG<\/jats:styled-content> axis was observed in intact female rats. <jats:styled-content style=\"fixed-case\">RLN<\/jats:styled-content>3 significantly increased the plasma levels of luteinising hormone and follicular\u2010stimulating hormone in male rats but not in female rats. Conversely, hypothalamic expression of gonadotrophin\u2010releasing hormone <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> was decreased by <jats:styled-content style=\"fixed-case\">RLN<\/jats:styled-content>3 in female rats but not in male rats. In addition, the plasma levels of oestradiol were significantly decreased by <jats:styled-content style=\"fixed-case\">RLN<\/jats:styled-content>3 administration in female rats. Consequently, intact <jats:styled-content style=\"fixed-case\">RLN<\/jats:styled-content>3\u2010injected female rats failed to display phasic inhibition of eating during oestrus. Sex\u2010specific effects of <jats:styled-content style=\"fixed-case\">RLN<\/jats:styled-content>3 on food intake and body weight were also observed in ovariectomised female and orchidectomised male rats, suggesting that the sex\u2010specific effects of <jats:styled-content style=\"fixed-case\">RLN<\/jats:styled-content>3 on energy metabolism are independent on the differential effects of <jats:styled-content style=\"fixed-case\">RLN<\/jats:styled-content>3 on <jats:styled-content style=\"fixed-case\">HPG<\/jats:styled-content> axis activity in male and female rats.<\/jats:p>","DOI":"10.1111\/jne.12439","type":"journal-article","created":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T21:04:33Z","timestamp":1481749473000},"source":"Crossref","is-referenced-by-count":11,"title":["Sex\u2010Specific Effects of Chronic Administration of Relaxin\u20103 on Food Intake, Body Weight and the Hypothalamic\u2010Pituitary\u2010Gonadal Axis in 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