{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:33:33Z","timestamp":1781105613501,"version":"3.54.1"},"reference-count":73,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,7,2]],"date-time":"2017-07-02T00:00:00Z","timestamp":1498953600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["0009"],"award-info":[{"award-number":["0009"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["0829"],"award-info":[{"award-number":["0829"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["PICT 2012\u20100009"],"award-info":[{"award-number":["PICT 2012\u20100009"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["PICT 2012\u20100820"],"award-info":[{"award-number":["PICT 2012\u20100820"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004462","name":"Consiglio Nazionale delle Ricerche","doi-asserted-by":"publisher","award":["PIP 112 20120100016"],"award-info":[{"award-number":["PIP 112 20120100016"]}],"id":[{"id":"10.13039\/501100004462","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["Ubacyt 20020130100418BA"],"award-info":[{"award-number":["Ubacyt 20020130100418BA"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>Damage observed in the hippocampus of the adult spontaneously hypertensive rat (<jats:styled-content style=\"fixed-case\">SHR<\/jats:styled-content>) resembles the neuropathology of mineralocorticoid\u2010induced hypertension, supporting a similar endocrine dysfunction in both entities. In the present study, we tested the hypothesis that increased expression of the hippocampal mineralocorticoid receptor (<jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">SHR<\/jats:styled-content> animals is associated with a prevalent expression of pro\u2010inflammatory over anti\u2010inflammatory factors. Accordingly, in the hippocampus, we measured <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression and immunoreactivity of the <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> and glucocorticoid receptor (<jats:styled-content style=\"fixed-case\">GR<\/jats:styled-content>) using a <jats:styled-content style=\"fixed-case\">quantitative polymerase chain reaction<\/jats:styled-content> and histochemistry. We also measured serum\u2010glucocorticoid\u2010activated kinase 1 (<jats:italic>Sgk1 <\/jats:italic><jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>), the number and phenotype of Iba1+ microglia, as well as <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression levels of the pro\u2010inflammatory factors cyclo\u2010oxygenase 2 (<jats:italic>Cox2<\/jats:italic>), <jats:italic>Nlrp3<\/jats:italic> inflammasome and tumour necrosis factor \u03b1 (<jats:italic>Tnf<\/jats:italic>\u03b1). Expression of anti\u2010inflammatory transforming growth factor (<jats:italic>Tgf<\/jats:italic>)\u03b2 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> and the <jats:styled-content style=\"fixed-case\">NADPH<\/jats:styled-content>\u2010diaphorase activity of nitric oxide synthase (<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>) were also determined. The results showed that, in the hippocampus of <jats:styled-content style=\"fixed-case\">SHR<\/jats:styled-content> rats, expression of <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> and the number of immunoreactive <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">GR<\/jats:styled-content> co\u2010expressing cells were increased compared to Wistar\u2010Kyoto control animals. Expression of <jats:italic>Sgk1<\/jats:italic>,<jats:italic> Cox2<\/jats:italic>,<jats:italic> Nlrp3<\/jats:italic> and the number of ramified glia cells positive for Iba1+ were also increased, whereas <jats:italic>Tgf<\/jats:italic>\u03b2 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression and the <jats:styled-content style=\"fixed-case\">NADPH<\/jats:styled-content>\u2010diaphorase activity of <jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content> were decreased. We propose that, in the <jats:styled-content style=\"fixed-case\">SHR<\/jats:styled-content> hippocampus, increased <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> expression causes a bias towards a pro\u2010inflammatory phenotype characteristic for hypertensive encephalopathy.<\/jats:p>","DOI":"10.1111\/jne.12489","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T04:22:39Z","timestamp":1495167759000},"source":"Crossref","is-referenced-by-count":27,"title":["Mineralocorticoid receptor associates with pro\u2010inflammatory bias in the hippocampus of spontaneously hypertensive rats"],"prefix":"10.1111","volume":"29","author":[{"given":"M. E.","family":"Brocca","sequence":"first","affiliation":[{"name":"Laboratory of Neuroendocrine Biochemistry Instituto de Biologia y Medicina Experimental\u2010CONICET  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Pietranera","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroendocrine Biochemistry Instituto de Biologia y Medicina Experimental\u2010CONICET  Buenos Aires Argentina"},{"name":"Department of Human Biochemistry Faculty of Medicine University of Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroendocrine Biochemistry Instituto de Biologia y Medicina Experimental\u2010CONICET  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lima","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroendocrine Biochemistry Instituto de Biologia y Medicina Experimental\u2010CONICET  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Roig","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroendocrine Biochemistry Instituto de Biologia y Medicina Experimental\u2010CONICET  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. R.","family":"de Kloet","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Internal Medicine Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3523-9148","authenticated-orcid":false,"given":"A. F.","family":"De Nicola","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroendocrine Biochemistry Instituto de Biologia y Medicina Experimental\u2010CONICET  Buenos Aires Argentina"},{"name":"Department of Human Biochemistry Faculty of Medicine University of Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000081314"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2006.01436.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1018958"},{"key":"e_1_2_6_5_1","first-page":"111","article-title":"Corticosteroid receptor plasticity in the central nervous system of various rat models","volume":"26","author":"Sutanto W","year":"1992","journal-title":"Endocr Regul"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-005-4011-5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2007.02.004"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2012.02332.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2012.174"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8229"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/10739680490266207"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/hy1001.091781"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(01)00362-1"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1385\/CBB:46:1:35"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.102285"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527315666160527155014"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2013.04.007"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.02.034"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(199705)20:1<23::AID-GLIA3>3.0.CO;2-6"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05333"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1187-07.2007"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145706"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2004.12.013"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1048"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1300886110"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.1.660"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000226054.53527.bb"},{"key":"e_1_2_6_28_1","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos G","year":"1997"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.04.007"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2012.00041"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6336(11)80102-6"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90184-4"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1089\/089771502753594918"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000368267"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/513251"},{"key":"e_1_2_6_37_1","doi-asserted-by":"crossref","first-page":"997","DOI":"10.33549\/physiolres.932064","article-title":"Alterations of NO synthase isoforms in brain and kidney of rats with genetic and salt hypertension","volume":"59","author":"Hojn\u00e1 S","year":"2010","journal-title":"Physiol Res"},{"key":"e_1_2_6_38_1","first-page":"97","article-title":"The endothelial mineralocorticoid receptor: mediator of the switch from vascular health to disease","volume":"26","author":"Davel AP","year":"2017","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2003.10.054"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c130044"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00847.2010"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000159937.05502.d1"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-13-04822.2001"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-1476"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.136242"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90742-8"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2845584"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.4853"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2007.11.009"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.109.4.787"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-2187"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1605246113"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90431-6"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2013.11.006"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1159\/000367849"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.10.048"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.07.094"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.190926"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1683"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.4406"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04691"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2010.07.005"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.227"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2015.02.013"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024369"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00018.2014"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20644"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507572102"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.10.005"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.96"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.11.019"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep21697"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1159\/000126973"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-014-0142-6"}],"container-title":["Journal of Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjne.12489","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.12489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T19:43:36Z","timestamp":1696189416000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jne.12489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":73,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1111\/jne.12489"],"URL":"https:\/\/doi.org\/10.1111\/jne.12489","archive":["Portico"],"relation":{},"ISSN":["0953-8194","1365-2826"],"issn-type":[{"value":"0953-8194","type":"print"},{"value":"1365-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7]]},"article-number":"jne.12489"}}