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Bariatric surgery procedures, including Roux\u2010en\u2010Y gastric bypass (<jats:styled-content style=\"fixed-case\">RYGB<\/jats:styled-content>), adjustable gastric banding (<jats:styled-content style=\"fixed-case\">AGB<\/jats:styled-content>) and sleeve gastrectomy (<jats:styled-content style=\"fixed-case\">SG<\/jats:styled-content>), have been the primary procedures conducted over the past decade, with <jats:styled-content style=\"fixed-case\">SG<\/jats:styled-content> increasing in popularity over the past 5\u00a0years at the expense of both <jats:styled-content style=\"fixed-case\">RYGB<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AGB<\/jats:styled-content>. Although these procedures were initially proposed to function via restrictive or malabsorptive mechanisms, it is now clear that profound physiological changes underlie the metabolic improvements in patients who undergo bariatric surgery. Data generated in human patients and animal models highlight the rapid and sustained changes in gut hormones that coincide with these procedures. Furthermore, recent studies highlight the involvement of the nervous system, specifically the vagus nerve, in mediating the reduction in appetite and food intake following bariatric surgery. What is unclear is where these pathways converge and interact within the gut\u2010brain axis and whether vagally\u2010mediated circuits are sufficient to drive the metabolic sequalae following bariatric surgery.<\/jats:p>","DOI":"10.1111\/jne.12534","type":"journal-article","created":{"date-parts":[[2017,9,9]],"date-time":"2017-09-09T03:32:38Z","timestamp":1504927958000},"source":"Crossref","is-referenced-by-count":30,"title":["Neuroendocrine mechanisms underlying bariatric surgery: Insights from human studies and animal models"],"prefix":"10.1111","volume":"29","author":[{"given":"A.","family":"Stefanidis","sequence":"first","affiliation":[{"name":"Department of Physiology Monash University  Clayton VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8609-6589","authenticated-orcid":false,"given":"B. 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