{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:41:00Z","timestamp":1787164860271,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["128316"],"award-info":[{"award-number":["128316"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>Negative energy balance promotes physiological adaptations that ensure the survival of animals. The hypothalamic\u2010pituitary\u2010thyroid axis regulates basal energy expenditure and its down\u2010regulating adaptation to negative energy balance is well described: in fasting, the serum content of thyrotrophin (TSH) and thyroid hormones (TH) decreases, enhancing the survival odds of individuals. By contrast, dehydration\u2010induced anorexic (DIA) rats present an impaired hypothalamic\u2010pituitary\u2010thyroid (HPT) axis adaptation despite their negative energy balance: increased circulating TSH levels. The implication of cocaine\u2010 and amphetamine\u2010regulated transcript (CART), an anorexic peptide, in HPT axis function impairment and food\u2010avoidance behaviour displayed by DIA animals is unknown. Because CART is co\u2010expressed with the peptide that regulates the HPT axis in hypophysiotrophic paraventricular nucleus (PVN) neurones (TSH\u2010releasing hormone), we analysed CART expression and possible implications with respect to high TSH levels of DIA animals. We examined whether changes in CART expression from the lateral hypothalamic area (LHA) and arcuate nucleus (ARC) could participate in food\u2010avoidance of DIA rats. DIA and forced\u2010food restricted (FFR) animals reduced their body weight and food intake. FFR rats had a down\u2010regulation of their HPT axis (reduced serum TH and TSH content), whereas DIA animals had reduced TH but increased TSH levels. CART mRNA expression in the ARC decreased similarly between experimental groups and diminished in anterior, medial PVN and in LHA of FFR animals, whereas DIA animals showed unchanged levels. This impaired CART mRNA expression in the anterior PVN and LHA could be related to the aberrant feeding behaviour of DIA rats but not to their deregulated HPT axis function.<\/jats:p>","DOI":"10.1111\/jne.12541","type":"journal-article","created":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T05:16:40Z","timestamp":1507267000000},"source":"Crossref","is-referenced-by-count":8,"title":["Impaired hypothalamic\n                    <scp>cocaine\u2010 and amphetamine\u2010regulated transcript<\/scp>\n                    expression in\n                    <scp>lateral hypothalamic area<\/scp>\n                    and\n                    <scp>paraventricular<\/scp>\n                    nuclei of dehydration\u2010induced anorexic rats"],"prefix":"10.1111","volume":"29","author":[{"given":"C.","family":"Garc\u00eda\u2010Luna","sequence":"first","affiliation":[{"name":"Molecular Neurophysiology Laboratory Department of Neurosciences Research National Institute of Psychiatry Ram\u00f3n de la Fuente Mu\u00f1iz  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Soberanes\u2010Ch\u00e1vez","sequence":"additional","affiliation":[{"name":"Molecular Neurophysiology Laboratory Department of Neurosciences Research National Institute of Psychiatry Ram\u00f3n de la Fuente Mu\u00f1iz  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9402-2061","authenticated-orcid":false,"given":"P.","family":"de Gortari","sequence":"additional","affiliation":[{"name":"Molecular Neurophysiology Laboratory Department of Neurosciences Research National Institute of Psychiatry Ram\u00f3n de la Fuente Mu\u00f1iz  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1450143"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.6.6062"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1210\/endo.136.7.7789304","article-title":"Changes in adrenal status affect hypothalamic thyrotropin\u2010releasing hormone gene expression in parallel with corticotropin\u2010releasing hormone","volume":"136","author":"Kakucska I","year":"1995","journal-title":"Endocrinology"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-220338"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0476"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1523\/JNEUROSCI.20-04-01550.2000","article-title":"alpha\u2010Melanocyte\u2010stimulating hormone is contained in nerve terminals innervating thyrotropin\u2010releasing hormone\u2010synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting\u2010induced suppression of prothyrotropin\u2010releasing hormone gene expression","volume":"20","author":"Fekete C","year":"2000","journal-title":"J Neurosci"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"9224","DOI":"10.1523\/JNEUROSCI.20-24-09224.2000","article-title":"Association of cocaine\u2010 and amphetamine\u2010regulated transcript\u2010immunoreactive elements with thyrotropin\u2010releasing hormone\u2010synthesizing neurons in the hypothalamic paraventricular nucleus and its role in the regulation of the hypothalamic\u2010pituitary\u2010thyroid axis during fasting","volume":"20","author":"Fekete C","year":"2000","journal-title":"J Neurosci"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8857"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)02619-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.138.6.5209"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1576"},{"key":"e_1_2_7_13_1","first-page":"224","article-title":"Direct effects of cocaine\u2010amphetamine\u2010regulated transcript (CART) on pituitary hormone release in pituitary cell culture","volume":"24","author":"Baranowska B","year":"2003","journal-title":"Neuro Endocrinol Lett"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2017.03.003"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)03312-6"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2004.05.006"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(01)00088-2"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200210070-00016"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.11.020"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2008.01758.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2006.03.035"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-10-j0006.1999"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1085"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200009280-00040"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0805fje"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/29993"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-14-06111.1999"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_7_29_1","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos G","year":"2005"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.11.009"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-0618(97)00212-3"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-2011"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2009.09.011"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2007.11.003"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2013.07.055"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801863"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2003.08.005"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0060347"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.04.051"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21316"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.03.023"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.09.054"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701471104"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10999"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2005.11.029"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.18.10833"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00572.2011"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2014.11.005"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6606-6-46"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-3042.2002.00775.x"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22017"}],"container-title":["Journal of Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjne.12541","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.12541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T06:10:09Z","timestamp":1694931009000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jne.12541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":50,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/jne.12541"],"URL":"https:\/\/doi.org\/10.1111\/jne.12541","archive":["Portico"],"relation":{},"ISSN":["0953-8194","1365-2826"],"issn-type":[{"value":"0953-8194","type":"print"},{"value":"1365-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11]]},"article-number":"e12541"}}