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Among them, retinoic acid (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>) functions as an important signalling molecule for vertebrate organogenesis in many tissues. However, little is known regarding the target genes in the developing pituitary. The present study aimed to clarify the relationship between endogenous <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> signalling and <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression of the pituitary\u2010specific transcription factor <jats:italic>Prop1<\/jats:italic> in the pituitary primordium of Rathke's pouch. Gene expression analysis and in situ hybridisation demonstrated that retinaldehyde dehydrogenases (<jats:italic>Raldhs<\/jats:italic>) and all types of <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> receptors (<jats:italic>Rars<\/jats:italic>) are expressed at the level of transcription in the rat Rathke's pouch. Ex vivo organ culture using Rathke's pouch and an in vitro reporter assay demonstrated that <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> signalling increases the expression level of <jats:italic>Prop1<\/jats:italic> via <jats:styled-content style=\"fixed-case\">RAR<\/jats:styled-content>\u03b1. Moreover, a reporter assay using serial truncated constructs of the 5\u2032<jats:italic>\u2010<\/jats:italic>upstream region of mouse <jats:italic>Prop1<\/jats:italic> revealed a predicted <jats:italic>cis<\/jats:italic>\u2010regulatory element of <jats:styled-content style=\"fixed-case\">RAR<\/jats:styled-content>\u03b1. This is the first report of a relationship between <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> signalling and <jats:italic>Prop1<\/jats:italic>\u2010expression during early pituitary development.<\/jats:p>","DOI":"10.1111\/jne.12570","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T16:30:14Z","timestamp":1516638614000},"source":"Crossref","is-referenced-by-count":18,"title":["Retinoic acid signalling is a candidate regulator of the expression of pituitary\u2010specific transcription factor <i>Prop1<\/i> in the developing rodent pituitary"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2574-6410","authenticated-orcid":false,"given":"S.","family":"Yoshida","sequence":"first","affiliation":[{"name":"Division of Life Science Graduate School of Agriculture Meiji University  Kawasaki Kanagawa Japan"},{"name":"Organization for the Strategic Coordination of Research and Intellectual Property 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