{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T17:15:51Z","timestamp":1783185351187,"version":"3.54.6"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009950","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2014R1A1A2054808"],"award-info":[{"award-number":["2014R1A1A2054808"]}],"id":[{"id":"10.13039\/100009950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007687","name":"Korean Diabetes Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>The hypothalamus is the regulatory centre of both appetite and energy balance and endoplasmic reticulum (<jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>) stress in the hypothalamus is involved in the pathogenesis of obesity. Recently, inhibition of 11 \u03b2 hydroxysteroid dehydrogenase type1 (11\u03b2\u2010<jats:styled-content style=\"fixed-case\">HSD<\/jats:styled-content>1) was reported to have an anti\u2010obesity effect by reducing fat mass. However, the link between the role of 11\u03b2\u2010<jats:styled-content style=\"fixed-case\">HSD<\/jats:styled-content>1 in the hypothalamus and obesity has yet to be determined. In the present study, embryonal primary hypothalamic neurones and high\u2010fat diet (<jats:styled-content style=\"fixed-case\">HFD<\/jats:styled-content>) fed mice were used to investigate the anorexigenic effects of 11\u03b2\u2010<jats:styled-content style=\"fixed-case\">HSD<\/jats:styled-content>1 inhibitors both in vitro and in vivo. In hypothalamic neurones, carbenoxolone (a non selecitve 11\u03b2\u2010<jats:styled-content style=\"fixed-case\">HSD<\/jats:styled-content> inhibitor) alleviated <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress and <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress\u2010induced neuropeptide alterations. In <jats:styled-content style=\"fixed-case\">HFD<\/jats:styled-content> mice, i.c.v. administration of carbenoxolone or <jats:styled-content style=\"fixed-case\">KR<\/jats:styled-content>67500 (nonselective and selective 11\u03b2\u2010<jats:styled-content style=\"fixed-case\">HSD<\/jats:styled-content>1 inhibitors, respectively) was associated with less weight gain compared to control mice for 24\u00a0hours after treatment, presumably by reducing food intake. Furthermore, glucose regulated protein (<jats:italic>Grp78<\/jats:italic>), spliced X\u2010box binding protein (<jats:italic>Xbp\u20101s<\/jats:italic>), c\/<jats:styled-content style=\"fixed-case\">EBP<\/jats:styled-content> homologous protein (<jats:italic>chop<\/jats:italic>) and <jats:styled-content style=\"fixed-case\">ER <\/jats:styled-content><jats:italic>DnaJ<\/jats:italic> homologue protein (<jats:italic>Erdj4<\/jats:italic>) expression was decreased in the hypothalami of mice administrated 11\u03b2\u2010<jats:styled-content style=\"fixed-case\">HSD<\/jats:styled-content>1 inhibitors compared to controls. Conversely, the phosphorylation of protein kinase B (<jats:styled-content style=\"fixed-case\">PKB<\/jats:styled-content>\/Akt), signal transducer and activator of transcription 3 (Stat3), mitogen\u2010activated protein kinase (<jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ERK<\/jats:styled-content>) and S6 kinase1 (S6K1) in the hypothalamus was induced more in mice treated using the same regimes. In conclusion, acute 11\u03b2\u2010<jats:styled-content style=\"fixed-case\">HSD<\/jats:styled-content>1 inhibition in the hypothalamus could reduce food intake by decreasing <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress and increasing insulin, leptin, and mammalian target of rapamycin complex 1 (<jats:styled-content style=\"fixed-case\">mTORC<\/jats:styled-content>1) signalling.<\/jats:p>","DOI":"10.1111\/jne.12580","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T13:06:34Z","timestamp":1518095194000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute anti\u2010obesity effects of intracerebroventricular 11\u03b2\u2010<scp>HSD<\/scp>1 inhibitor administration in diet\u2010induced obese mice"],"prefix":"10.1111","volume":"30","author":[{"given":"M.","family":"Seo","sequence":"first","affiliation":[{"name":"Medical Institute of Dongguk University  Gyeongju South Korea"},{"name":"Department of Agricultural Biology National Institute of Agricultural Sciences Rural Development Administration  Wanju\u2010gun South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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