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Arginine vasopressin, which regulates fluid homeostasis, is secreted by magnocellular neurosecretory cells (<jats:styled-content style=\"fixed-case\">MNC<\/jats:styled-content>s) of the hypothalamic supraoptic nucleus. <jats:styled-content style=\"fixed-case\">Arginine vasopressin<\/jats:styled-content> secretion by <jats:styled-content style=\"fixed-case\">MNC<\/jats:styled-content>s is regulated by both excitatory and inhibitory synaptic activity, alterations in plasma osmolarity and various peptides, including angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>. In the present study, we used whole\u2010cell patch\u2010clamp recordings of brain slices to determine whether hyperosmotic stimulation and\/or angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> potentiate excitatory synaptic input in a rat model of cancer cachexia, similar to their effects in normal (control) rats. Hyperosmotic (15 and 60 <jats:styled-content style=\"fixed-case\">mmol\u00a0L<jats:sup>\u20101<\/jats:sup>\u00a0<\/jats:styled-content> mannitol) stimulation and angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (0.1\u00a0\u03bcmol\u00a0L<jats:sup>\u20101<\/jats:sup>) increased the frequency, but not the amplitude, of miniature excitatory postsynaptic currents in normal rats; in model rats, both effects were significantly attenuated. These results suggest that cancer cachexia alters supraoptic <jats:styled-content style=\"fixed-case\">MNC<\/jats:styled-content> sensitivity to osmotic and angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> stimulation.<\/jats:p>","DOI":"10.1111\/jne.12630","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T20:39:02Z","timestamp":1530045542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modulation of synaptic inputs in magnocellular neurones in a rat model of cancer cachexia"],"prefix":"10.1111","volume":"30","author":[{"given":"Toru","family":"Yokoyama","sequence":"first","affiliation":[{"name":"Cancer Pathophysiology Division National Cancer Center Research Institute  Tokyo Japan"},{"name":"Department of Physiology School of Medicine University of Occupational and Environmental Health  Kitakyushu Japan"},{"name":"Department of Anesthesiology and Critical Care Medicine Jichi Medical University  Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Terawaki","sequence":"additional","affiliation":[{"name":"Cancer Pathophysiology Division National Cancer Center Research Institute  Tokyo Japan"},{"name":"Tsumura Research Laboratories Tsumura &amp; Co.  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