{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:17:45Z","timestamp":1790759865800,"version":"4.1.0"},"reference-count":95,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,7]],"date-time":"2018-10-07T00:00:00Z","timestamp":1538870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["319818"],"award-info":[{"award-number":["319818"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>The communication between the gut and the brain is important for the control of energy homeostasis. In response to food intake, enteroendocrine cells secrete gut hormones, which ultimately suppress appetite through centrally\u2010mediated processes. Increasing evidence implicates the vagus nerve as an important conduit in transmitting these signals from the gastrointestinal tract to the brain. Studies have demonstrated that many of the gut hormones secreted from enteroendocrine cells signal through the vagus nerve, and the sensitivity of the vagus to these signals is regulated by feeding status. Furthermore, evidence suggests that a reduction in the ability of the vagus nerve to respond to the switch between a \u201cfasted\u201d and \u201cfed\u201d state, retaining sensitivity to orexigenic signals when fed or a reduced ability to respond to satiety hormones, may contribute to obesity. This review draws together the evidence that the vagus nerve is a crucial component of appetite regulation via the gut\u2010brain axis, with a particular emphasis on experimental techniques and future developments.<\/jats:p>","DOI":"10.1111\/jne.12643","type":"journal-article","created":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T10:03:59Z","timestamp":1536660239000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["The role of the vagus nerve in appetite control: Implications for the pathogenesis of obesity"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5720-9751","authenticated-orcid":false,"given":"Simon C.","family":"Cork","sequence":"first","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine Division of Endocrinology, Diabetes and Metabolism Imperial College London London 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