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However, no specific ghrelin targeting anti\u2010obesity or cachexia therapeutics are available for clinical use thus far and further efforts in this direction are warranted. The present study aimed to find new peptide drug leads modulating ghrelin signal transduction. By targeting neutralising antibodies against ghrelin with phage display libraries, we aimed to identify peptides binding to the cognate receptor. Four synthetic peptides were selected and tested using calcium screening assays. The most effective competitive antagonist <jats:styled-content style=\"fixed-case\">FSFLPPE<\/jats:styled-content> was further tested in vivo. Administration of the peptide produced no significant effect on either food intake or <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> release. Surprisingly, when co\u2010administered with ghrelin, the peptide significantly enhanced <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> secretion and c\u2010Fos expression. The evidence obtained in the present study indicates that <jats:styled-content style=\"fixed-case\">FSFLPPE<\/jats:styled-content> might act as an ago\u2010allosteric modulator.<\/jats:p>","DOI":"10.1111\/jne.12656","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T11:49:15Z","timestamp":1541418555000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Peptide mimetic of N\u2010terminal ghrelin enhances ghrelin\u2010induced growth hormone secretion and c\u2010Fos expression in mice"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9448-789X","authenticated-orcid":false,"given":"Mojca","family":"Lunder","sequence":"first","affiliation":[{"name":"Chair of Pharmaceutical Biology Faculty of Pharmacy University of Ljubljana Ljubljana 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