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Circadian clocks are self\u2010sustained cellular oscillators based on a set of clock genes\/proteins organised in interlocked transcriptional\u2010translational feedback loops. The body's clocks need to be regularly reset and synchronised with each other to achieve coherent rhythmic output signals. This synchronisation is achieved by interplay of a master clock, which resides in the suprachiasmatic nucleus, and peripheral tissue clocks. This clock network is reset by time signals such as the light\/dark cycle, food intake and activity. The balanced interplay of clocks is easily disturbed in modern society by shiftwork or high\u2010energy diets, which may further promote the development of metabolic disorders. In this review, we summarise the current model of central\u2010peripheral clock interaction in metabolic health. Different established mouse models for central or peripheral clock disruption and their metabolic phenotypes are compared and the possible relevance of clock network interaction for the development of therapeutic approaches in humans is discussed.<\/jats:p>","DOI":"10.1111\/jne.12659","type":"journal-article","created":{"date-parts":[[2018,11,11]],"date-time":"2018-11-11T08:58:53Z","timestamp":1541926733000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Interplay of central and peripheral circadian clocks in energy metabolism regulation"],"prefix":"10.1111","volume":"31","author":[{"given":"Isa","family":"Kolbe","sequence":"first","affiliation":[{"name":"Institute of Neurobiology University of Lubeck Lubeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Brehm","sequence":"additional","affiliation":[{"name":"Institute of Neurobiology University of Lubeck Lubeck 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