{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T10:45:35Z","timestamp":1775299535964,"version":"3.50.1"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T00:00:00Z","timestamp":1546732800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP15H04394"],"award-info":[{"award-number":["JP15H04394"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18H02473"],"award-info":[{"award-number":["JP18H02473"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Sulphated cholecystokinin octapeptide (CCK\u20108s) is involved in feeding regulation as an anorexigenic neuropeptide in vertebrates. In rodents, i.c.v. administration of CCK\u20108s has been shown to affect not only feeding behaviour, but also psychomotor activity. However, there is still no information available concerning the psychophysiological effects of CCK\u20108s in goldfish. Therefore, in the present study, we examined the effect of synthetic goldfish (gf) CCK\u20108s on psychomotor activity in this species. Intracerebroventricular administration of gfCCK\u20108s at 0.1, 0.5 and 2.5\u00a0pmol\u00a0g\n                      <jats:sup>\u20101<\/jats:sup>\n                      body weight (BW) did not affect swimming distance (locomotor activity). Because goldfish prefer the lower to the upper area of a tank, we used this as a preference test (upper\/lower test) to assess anxiety\u2010like behaviour. Intracerebroventricular administration of gfCCK\u20108s at 2.5\u00a0pmol\u00a0g\n                      <jats:sup>\u20101<\/jats:sup>\n                      BW shortened the time spent in the upper area. The action of gfCCK\u20108s mimicked that of FG\u20107142 (the central\u2010type benzodiazepine receptor inverse agonist, an anxiogenic agent) at 5 and 10\u00a0pmol\u00a0g\n                      <jats:sup>\u20101<\/jats:sup>\n                      BW. The anxiogenic\u2010like effect of gfCCK\u20108s was abolished by treatment with the CCK receptor antagonist proglumide at 50\u00a0pmol\u00a0g\n                      <jats:sup>\u20101<\/jats:sup>\n                      BW. We also investigated the localisation of CCK\/gastrin\u2010like immunoreactivity in the goldfish brain. CCK\/gastrin\u2010like immunoreactivity was observed in the anxiety\u2010related regions (the nucleus habenularis and the interpeduncular nucleus). These data indicate that gfCCK\u20108s potently affects psychomotor activity in goldfish, and exerts an anxiogenic\u2010like effect via the CCK receptor\u2010signalling pathway.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jne.12667","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T13:42:09Z","timestamp":1544103729000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Intracerebroventricular administration of sulphated cholecystokinin octapeptide induces anxiety\u2010like behaviour in goldfish"],"prefix":"10.1111","volume":"31","author":[{"family":"Sachuriga","sequence":"first","affiliation":[{"name":"Laboratory of Regulatory Biology Graduate School of Science and Engineering University of Toyama Toyama 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