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The present study aimed to explore the intra and inter network resting state functional connectivity changes underlying the neurobehavioural symptoms in thyrotoxicosis. To understand the pathophysiological changes, we investigated the correlation between functional connectivity and clinical and behavioural measures. Twenty\u2010eight freshly diagnosed thyrotoxicosis patients suffering with symptoms such as palpitation, loss of weight, trembling and heat intolerance from days to weeks and 28 healthy controls were recruited for the study. Thyrotoxicosis patients showed significantly decreased functional connectivity in sensorimotor network, fronto\u2010temporal network, default mode network, right fronto\u2010parietal network, left fronto\u2010parietal network and salience network. Inter network functional connectivity was significantly reduced between the basal ganglia network and <jats:styled-content style=\"fixed-case\">sensorimotor network<\/jats:styled-content> and increased between the <jats:styled-content style=\"fixed-case\">salience network<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">fronto\u2010temporal network<\/jats:styled-content> in thyrotoxicosis. Cognitive functions such as visual retention, recognition of objects, mental balance and performance on neuropsychological tests (ie, the Bender Gestalt test, Nahar\u2010Benson test and Mini Mental State Examination) also showed significant decline in thyrotoxicosis patients. The altered intrinsic resting state functional connectivity might underlie these cognitive deficits. The increased functional connectivity between the <jats:styled-content style=\"fixed-case\">salience network<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">fronto\u2010temporal network<\/jats:styled-content> suggests the recruitment of additional neuronal circuitry needed to compensate for the neuropathology in the primary neural network in thyrotoxicosis.<\/jats:p>","DOI":"10.1111\/jne.12683","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T05:24:40Z","timestamp":1546406680000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Aberrant intra and inter network resting state functional connectivity in thyrotoxicosis"],"prefix":"10.1111","volume":"31","author":[{"given":"Mukesh","family":"Kumar","sequence":"first","affiliation":[{"name":"NMR Research Centre Institute of Nuclear Medicine and Allied Sciences (INMAS), DRDO New Delhi 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