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Before obtaining its own microbiota, eutherian foetuses are exposed to products and metabolites from the maternal microbiota. At birth, the infants are colonised by microorganisms. The microbial composition in early life is strongly influenced by the mode of delivery, the feeding method, the use of antibiotics and the maternal microbial composition. Microbial products and microbially produced metabolites act as signalling molecules that have direct or indirect effects on the <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> and the <jats:styled-content style=\"fixed-case\">ENS<\/jats:styled-content>. An increasing number of studies show that the gut microbiota can modulate important processes during development, including neurogenesis, myelination, glial cell function, synaptic pruning and blood\u2010brain barrier permeability. Furthermore, numerous studies indicate that there is a developmental window early in life during which the gut microbial composition is crucial and perturbation of the gut microbiota during this period causes long\u2010lasting effects on the development of the <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> and the <jats:styled-content style=\"fixed-case\">ENS<\/jats:styled-content>. However, other functions are readily modulated in adult animals, including microglia activation and neuroinflammation. Several neurobehavioural, neurodegenerative, mental and metabolic disorders, including Parkinson disease, autism spectrum disorder, schizophrenia, Alzheimer's disease, depression and obesity, have been linked to the gut microbiota. This review focuses on the role of the microorganisms in the development and function of the <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> and the <jats:styled-content style=\"fixed-case\">ENS<\/jats:styled-content>, as well as their potential role in pathogenesis.<\/jats:p>","DOI":"10.1111\/jne.12684","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T20:26:48Z","timestamp":1546979208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":282,"title":["The role of the gut microbiota in development, function and disorders of the central nervous system and the enteric nervous system"],"prefix":"10.1111","volume":"31","author":[{"given":"Christina N.","family":"Heiss","sequence":"first","affiliation":[{"name":"Wallenberg Laboratory Department of Molecular and Clinical Medicine Institute of Medicine University of Gothenburg Gothenburg 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