{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T02:44:17Z","timestamp":1761965057857,"version":"3.41.2"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T00:00:00Z","timestamp":1551830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1084600","1084344"],"award-info":[{"award-number":["1084600","1084344"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>Information about metabolic status arrives in the brain in the form of a complex milieu of circulating signalling factors, including glucose and fatty acids, ghrelin, leptin and insulin. The specific interactions between humoural factors, brain sites of action and how they influence behaviour are largely unknown. We have previously observed interactions between glucose availability and the actions of ghrelin mediated via the agouti\u2010related peptide neurones of the hypothalamus. In the present study, we examine whether these effects generalise to another ghrelin\u2010sensitive brain nucleus, the ventral tegmental area (<jats:styled-content style=\"fixed-case\">VTA<\/jats:styled-content>). We altered glucose availability by injecting mice with glucose or 2\u2010deoxyglucose i.p. to induce hyperglycaemia and glucopenia, respectively. Thirty minutes later, we injected ghrelin in the <jats:styled-content style=\"fixed-case\">VTA<\/jats:styled-content>. Glucose administration suppressed intra\u2010<jats:styled-content style=\"fixed-case\">VTA<\/jats:styled-content> ghrelin\u2010induced feeding. Leptin, a longer\u2010term signal of positive energy balance, did not affect intra\u2010<jats:styled-content style=\"fixed-case\">VTA<\/jats:styled-content> ghrelin\u2010induced feeding. 2\u2010Deoxyglucose and ghrelin both increased food intake in their own right and, together, they additively increased feeding. These results add support to the idea that calculation of metabolic need depends on multiple signals across multiple brain regions and identifies that <jats:styled-content style=\"fixed-case\">VTA<\/jats:styled-content> circuits are sensitive to the integration of signals reflecting internal homeostatic state and influencing food intake.<\/jats:p>","DOI":"10.1111\/jne.12696","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T17:18:45Z","timestamp":1549905525000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Glucose availability regulates ghrelin\u2010induced food intake in the ventral tegmental area"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3833-4714","authenticated-orcid":false,"given":"Sarah H.","family":"Lockie","sequence":"first","affiliation":[{"name":"Monash Biomedicine Discovery Institute Monash University Clayton Victoria 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