{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T10:15:34Z","timestamp":1769854534558,"version":"3.49.0"},"reference-count":73,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T00:00:00Z","timestamp":1557273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31460565"],"award-info":[{"award-number":["31460565"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31260513"],"award-info":[{"award-number":["31260513"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dyadic physical social interaction influences cocaine\u2010seeking behaviour, although whether limited sexual cues (LSC) from an opposite\u2010sex partner influence the behavioural responses to cocaine is unclear. We investigated this issue using a cylindrical wire cage containing a stimulus mouse; the subject mouse (of the opposite sex)\u00a0had access to this stimulus mouse during a \u201cbinge\u201d injection pattern (injected with cocaine or saline vehicle twice a day at 6\u2010hour intervals). Following the second injection, locomotion and anxiety\u2010like behaviours were examined using the open\u2010field and elevated plus maze test, at the same time as oestrogen receptor (ER)\u03b1 and tyrosine hydroxylase (TH) immunoreactivities were also examined. The data indicate that LSC enhanced cocaine\u2010stimulated locomotion in both sexes and inhibited the levels of anxiety caused by cocaine in males only. Accompanying these changes, the interaction between LSC and cocaine altered ER\u03b1 immunoreactivity in the ventral medial nuclei of the hypothalamus (VMH) and medial amygdaloid nucleus (MeA) of males, whereas such interaction effects occurred in the VMH, MeA, arcuate nucleus (AR), bed nucleus of the stria terminalis (BNST) and lateral septum (LS) of females. LSC increased cocaine\u2010induced ER\u03b1 immunoreactivity in the VMH in males and reduced cocaine\u2010induced ER\u03b1 immunoreactivity in the AR and LS in females. LSC up\u2010regulated cocaine\u2010induced increases in ventral tegmental area (VTA) TH immunoreactivity in females only. Our present data suggest that interactions between LSC and cocaine led to changes in ER\u03b1 and TH immunoreactivity in a brain\u00a0region\u2010specific manner, which showed subtle differences in both sexes. The effects of LSC\u2010mediated cocaine\u2010induced locomotion and anxiety may be associated with alterations in ER\u03b1 and dopamine activation.<\/jats:p>","DOI":"10.1111\/jne.12720","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T15:29:51Z","timestamp":1555946991000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sexual cues influence cocaine\u2010induced locomotion, anxiety and the immunoreactivity of oestrogen receptor alpha and tyrosine hydroxylase in both sexes"],"prefix":"10.1111","volume":"31","author":[{"given":"Chen","family":"He","sequence":"first","affiliation":[{"name":"College of Biological Sciences and Engineering North Minzu University Yinchuan Ningxia China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1672-4970","authenticated-orcid":false,"given":"Jianli","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Biological Sciences and Engineering North Minzu University Yinchuan Ningxia China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Biological Sciences and Engineering North Minzu University Yinchuan Ningxia China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Biological Sciences and Engineering North Minzu University Yinchuan Ningxia China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2010.00285.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/pha0000078"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e32835f1719"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-012-2737-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2004.00071.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2008.02.013"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2008.08.003"},{"key":"e_1_2_7_9_1","first-page":"404","article-title":"Effects of different context peer reinforcing and oxytocin treatment on cocaine CPP in female mandarin voles","volume":"36","author":"Wang JL","year":"2016","journal-title":"Acta Theriologica Sinica"},{"key":"e_1_2_7_10_1","first-page":"80","article-title":"Conditioned place preference for social interaction in rats: contribution of sensory components","volume":"5","author":"Kummer K","year":"2011","journal-title":"Front Behav Neurosci"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91309-5"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.106.1.181"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.10.001"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2012.03.017"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2010_93"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1183-2"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2007.07.003"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.04.015"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2009.12.003"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2004.04.009"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-016-4368-9"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035538"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.05.010"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.05.078"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e328358603c"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2011.04.017"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-9081-7-29"},{"key":"e_1_2_7_28_1","first-page":"426","article-title":"Differences in cocaine\u2010induced place preference persistence, locomotion and social behaviors between C57BL\/6J and BALB\/cJ mice","volume":"35","author":"Wang JL","year":"2014","journal-title":"Zool Res"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(99)00072-8"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.07.026"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.60.111"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.04.042"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.01.056"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.08.025.2009"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.02.064"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2004.08.001"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2004.06.008"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1587-7"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(87)90227-7"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(89)90195-9"},{"key":"e_1_2_7_41_1","first-page":"127","article-title":"Oxytocin: the great facilitator of life","volume":"88","author":"Lee HJ","year":"2009","journal-title":"Prog Neurobiol"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-12-05329.2003"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.02.033"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00112"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2015.03.041"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13788"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.05.012"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2529-07.2007"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1158"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)91536-N"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-11-07261.1995"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2011.02.005"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00902.2007"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2008.04.015"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008931"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2011.02210.x"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)02807-X"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3801-04.2005"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.03.006"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2014.11.013"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2011.05.005"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069943"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.0.1220847"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-09-03236.2001"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.80.1.1"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2010.01958.x"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2010.03.020"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-185277-1.50014-9"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FP0070653"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707646105"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.97"},{"key":"e_1_2_7_72_1","first-page":"591","article-title":"The modulatory role of dopamine in anxiety\u2010like behavior","volume":"18","author":"Zarrindast MR","year":"2015","journal-title":"Arch Iran Med"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20937"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(88)90049-2"}],"container-title":["Journal of Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjne.12720","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.12720","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jne.12720","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.12720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T17:01:01Z","timestamp":1694365261000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jne.12720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,8]]},"references-count":73,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/jne.12720"],"URL":"https:\/\/doi.org\/10.1111\/jne.12720","archive":["Portico"],"relation":{},"ISSN":["0953-8194","1365-2826"],"issn-type":[{"value":"0953-8194","type":"print"},{"value":"1365-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,8]]},"assertion":[{"value":"2018-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12720"}}