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This control revolves around the hypothalamic\u2010pituitary\u2010gonadal axis, which operates under traditional homeostatic feedback by sex steroids from the gonads in males and most of the time in females. An exception is the late follicular phase in females, when homeostatic feedback is suspended and a positive\u2010feedback response to oestradiol initiates the preovulatory surges of GnRH and luteinising hormone. Here, we briefly review the history of how mechanisms underlying central control of ovulation by circulating steroids have been studied, discuss the relative merit of different model systems and integrate some of the more recent findings in this area into an overall picture of how this phenomenon occurs.<\/jats:p>","DOI":"10.1111\/jne.12724","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T10:14:46Z","timestamp":1557137686000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Central aspects of systemic oestradiol negative\u2010 and positive\u2010feedback on the reproductive neuroendocrine system"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9812-0497","authenticated-orcid":false,"given":"Suzanne M.","family":"Moenter","sequence":"first","affiliation":[{"name":"Department of Molecular and Integrative Physiology University of Michigan Ann 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