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Although increased weight gain results from a combination of poor dietary habits and decreased energy expenditure, not all individuals have equal propensities to gain weight or to develop secondary complications of obesity. This is partially a result not only of genetics, including sex, but also the time during which an individual is exposed to an obesogenic environment. In the present study, we have compared the response of male and female mice to short\u2010term exposure to a high\u2010fat diet (<jats:styled-content style=\"fixed-case\">HFD<\/jats:styled-content>) or a low\u2010fat diet during the peripubertal period (starting at 42\u00a0days of age) because this is a stage of dramatic hormonal and metabolic modifications. After 1\u00a0week on a <jats:styled-content style=\"fixed-case\">HFD<\/jats:styled-content>, there was no significant increase in body weight, although females significantly increased their energy intake. Serum leptin levels increased in both sexes, even though no change in fat mass was detected. Glyceamia and homeostasis model assessment increased in males, suggesting a rapid change in glucose metabolism. Hypothalamic pro\u2010opiomelanocortin <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> levels were significantly higher in females on a <jats:styled-content style=\"fixed-case\">HFD<\/jats:styled-content> compared to all other groups, which may be an attempt to reduce their increased energy intake. Hypothalamic inflammation and gliosis have been implicated in the development of secondary complications of obesity; however, no indication of activation of inflammatory processes or gliosis was found in response to 1\u00a0week of <jats:styled-content style=\"fixed-case\">HFD<\/jats:styled-content> in the hypothalamus, hippocampus or cerebellum of these young mice. These results indicate that there are both sex and age effects in the response to poor dietary intake because peripubertal male and female mice respond differently to short\u2010term dietary changes and this response is different from that reported in adult rodents.<\/jats:p>","DOI":"10.1111\/jne.12756","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T08:55:13Z","timestamp":1560156913000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Sex differences in the peripubertal response to a short\u2010term, high\u2010fat diet intake"],"prefix":"10.1111","volume":"32","author":[{"given":"Alejandra","family":"Freire\u2010Regatillo","sequence":"first","affiliation":[{"name":"Department of Endocrinology Hospital Infantil Universitario Ni\u00f1o Jes\u00fas Instituto de Investigaci\u00f3n la Princesa Madrid Spain"},{"name":"Department of Pediatrics Facultad de Medicina Universidad 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