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Salt and additional amounts of fluid are the main treatment for this disorder. Similarly, experimental lesions to these brain regions, which include the median eminence (<jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content>), produce a well\u2010documented neurological model of polydipsia and polyuria in rats, which is preceded by an early sodium excretion of unknown cause. In the present study, oxytocin (<jats:styled-content style=\"fixed-case\">OT<\/jats:styled-content>) was used to increase the renal sodium loss and prolong the hydroelectrolyte abnormalities of<jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content>\u2010lesioned animals during the first few hours post\u2010surgery. The objective was to determine whether<jats:styled-content style=\"fixed-case\">OT<\/jats:styled-content>\u2010treated<jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content>\u2010lesioned animals increase their sodium appetite and water intake to restore the volume and composition of extracellular body fluid. Electrolytic lesion of the<jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content>increased water intake, urinary volume and sodium excretion of food\u2010deprived rats and also decreased urine osmolality and estimated plasma sodium concentration.<jats:styled-content style=\"fixed-case\">OT<\/jats:styled-content>administration at 8\u00a0hours post\u2010surgery reduced water intake, urine output and plasma sodium concentration and also increased urine osmolality and urine sodium excretion between 8 and 24\u00a0hours post\u2010lesion. From 24 to 30\u00a0hours, more water and hypertonic NaCl was consumed by<jats:styled-content style=\"fixed-case\">OT<\/jats:styled-content>\u2010treated<jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content>\u2010lesioned rats than by physiological saline\u2010treated\u2010<jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content>\u2010lesioned animals. Food availability from 30 to 48\u00a0hours reduced the intake of hypertonic saline solution by<jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">OT<\/jats:styled-content>animals, which increased their water and food intake during this period.<jats:styled-content style=\"fixed-case\">OT<\/jats:styled-content>administration therefore appears to enhance the natriuretic effect of<jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content>lesion, producing hydroelectrolyte changes that reduce the water intake of food\u2010deprived animals. Conversely, the presence of hypertonic NaCl increases the fluid intake of these animals, possibly as a result of the plasma sodium depletion and hypovolaemic states previously generated. Finally, the subsequent increase in food intake by<jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">OT<\/jats:styled-content>animals reduces their need for hypertonic NaCl but not water, possibly in response to osmotic thirst. These results are discussed in relation to a possible transient activation of the<jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content>with the consequent secretion of natriuretic peptides stored in terminal swellings, which would be augmented by<jats:styled-content style=\"fixed-case\">OT<\/jats:styled-content>administration. Electrolytic lesion of the<jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content>may therefore represent a useful neurobiological model of<jats:styled-content style=\"fixed-case\">CSW<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jne.12778","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T17:24:15Z","timestamp":1565285055000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of oxytocin administration on the hydromineral balance of median eminence\u2010lesioned rats"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9763-7627","authenticated-orcid":false,"given":"Javier","family":"Mah\u00eda","sequence":"first","affiliation":[{"name":"Department of Psychobiology and Mind, Brain and Behavior Research Center (CIMCYC) University of Granada Granada 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