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Prenatal exposure to drugs of abuse, including opioids, alcohol, cocaine and cannabis, has been shown to not only impact <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> signalling, but also alter functioning of the hypothalamic\u2010pituitary\u2010adrenal (<jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>) axis. Such exposures can have long\u2010lasting neurobehavioural consequences, including alterations in the stress response in the offspring. Furthermore, cannabis contains cannabinoids that signal via the <jats:styled-content style=\"fixed-case\">eCB<\/jats:styled-content> pathway, which is linked to some components of <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> signalling in the adult brain. Given that <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>s are frequently used in pregnancy to prevent complications of prematurity, and also that rates of cannabis use in pregnancy are increasing, the likelihood of foetal co\u2010exposure to these compounds is high and may have additional implications for long\u2010term neurodevelopment. Here, we present a discussion of <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> signalling and the <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content> axis, as well as the effects of prenatal drug exposure on these pathways and the stress response, and we explore the interactions between <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content> signalling in the developing brain and potential for neurodevelopmental consequences.<\/jats:p>","DOI":"10.1111\/jne.12786","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T13:14:12Z","timestamp":1567170852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Prenatal drug exposure and neurodevelopmental programming of glucocorticoid signalling"],"prefix":"10.1111","volume":"32","author":[{"given":"Alexis 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