{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:28:48Z","timestamp":1790738928700,"version":"4.1.0"},"reference-count":95,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH81816"],"award-info":[{"award-number":["MH81816"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH81816\u2010S1"],"award-info":[{"award-number":["MH81816\u2010S1"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["P50 MH078105\u201004S1"],"award-info":[{"award-number":["P50 MH078105\u201004S1"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["P51OD011132"],"award-info":[{"award-number":["P51OD011132"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Preclinical studies demonstrate that chronic stress modulates the effects of oestradiol (E2) on behaviour through the modification of the amygdala and the medial prefrontal cortex (mPFC) neuronal structure. Clinical studies suggest that alterations in amygdala functional connectivity (FC) with the mPFC may be associated with stress\u2010related phenotypes, including mood and anxiety disorders. Thus, identifying the effects of stress and E2 on amygdala\u2010mPFC circuits is critical for understanding the neurobiology underpinning the vulnerability to stress\u2010related disorders in women. In the present study, we used a well\u2010validated rhesus monkey model of chronic psychosocial stress (subordinate social rank) to examine effects of E2 on subordinate (SUB) (i.e. high stress) and dominant (DOM) (i.e. low stress) female resting\u2010state amygdala FC with the mPFC and with the whole\u2010brain. In the non\u2010E2 treatment control condition, SUB was associated with stronger left amygdala FC to subgenual cingulate (Brodmann area [BA] 25: BA25), a region implicated in several psychopathologies in people. In SUB females, E2 treatment strengthened right amygdala\u2010BA25 FC, induced a net positive amygdala\u2010visual cortex FC that was positively associated with frequency of submissive behaviours, and weakened positive amygdala\u2010para\/hippocampus FC. Our findings show that subordinate social rank alters amygdala FC and the impact of E2 on amygdala FC with BA25 and with regions involved in visual processing and memory encoding.<\/jats:p>","DOI":"10.1111\/jne.12822","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T18:27:35Z","timestamp":1576607255000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of social subordination and oestradiol on resting\u2010state amygdala functional connectivity in adult female rhesus monkeys"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1910-127X","authenticated-orcid":false,"given":"Katherine M.","family":"Reding","sequence":"first","affiliation":[{"name":"Division of Developmental and Cognitive Neuroscience Yerkes National Primate Research Center Emory University Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Grayson","sequence":"additional","affiliation":[{"name":"Center for Neuroscience University of California\u00a0\u2013\u00a0Davis Davis CA USA"},{"name":"Departments of Behavioral Neuroscience, Psychiatry, and Advanced Imaging Research Center Oregon Health and Science University Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Miranda\u2010Dominguez","sequence":"additional","affiliation":[{"name":"Departments of Behavioral Neuroscience, Psychiatry, and Advanced Imaging Research Center Oregon Health and Science University Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddarth","family":"Ray","sequence":"additional","affiliation":[{"name":"Departments of Behavioral Neuroscience, Psychiatry, and Advanced Imaging Research Center Oregon Health and Science University Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Division of Developmental and Cognitive Neuroscience Yerkes National Primate Research Center Emory University Atlanta GA USA"},{"name":"Department of Psychiatry &amp; Behavioral Sciences Emory University Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Toufexis","sequence":"additional","affiliation":[{"name":"Department of Psychological Science University of Vermont Burlington VT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien A.","family":"Fair","sequence":"additional","affiliation":[{"name":"Departments of Behavioral Neuroscience, Psychiatry, and Advanced Imaging Research Center Oregon Health and Science University Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar M.","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Division of Developmental and Cognitive Neuroscience Yerkes National Primate Research Center Emory University Atlanta GA USA"},{"name":"Department of Psychiatry &amp; Behavioral Sciences Emory University Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.clinpsy.1.102803.143938"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.14.1685"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.36"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1067965"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.07.061"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1586\/ern.10.198"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.09.034"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19971201)388:4<507::AID-CNE1>3.0.CO;2-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-0102(96)01105-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2012.09.010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2011.02.002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2003.10.001"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300708"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-009-8079-7"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.04.057"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq003"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.04.025"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.05.036"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.05.031"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.03.015"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.02.064"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.09.012"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.1995.7.1.1"},{"key":"e_1_2_7_25_1","volume-title":"The Prefrontal Cortex: Anatomy, Physiology, and Neuropsychology of the Frontal Lobe","author":"Fuster JM","year":"1997"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0271-06.2006"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.3.206"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903100402"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903100404"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(00)00035-2"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.08.005"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.03.011"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990607)408:3<365::AID-CNE5>3.0.CO;2-N"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-12-04657.2000"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2006.06.012"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(98)00197-X"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00443-1"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1995.tb44715.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(96)00185-0"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2011.12.004"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2012.07.014"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2012.02.002"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajp.20706"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-30872-2_2"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb09278.x"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2007.11.042"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12009"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.109.079038"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq288"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod27.3.530"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1163\/156853974X00534"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2005.07.005"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05758"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4229-13.2014"},{"key":"e_1_2_7_55_1","first-page":"10.1117\/12.7100","article-title":"Automatic brain segmentation in rhesus monkeys","volume":"6512","author":"Styner M","year":"2007","journal-title":"Med imaging"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.018"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2014.00007"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp166"},{"key":"e_1_2_7_59_1","volume-title":"The Rhesus Monkey Brain in Stereotaxic Coordinates","author":"Paxinos G","year":"2000"},{"key":"e_1_2_7_60_1","volume-title":"A Combined MRI and Histology Atlas of the Rhesus Monkey Brain in Stereotaxic Coordinates","author":"Saleem KS","year":"2006"},{"key":"e_1_2_7_61_1","first-page":"279","volume-title":"Handbook of Chemical Neuroanatomy","author":"Price JL","year":"1987"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20001204)428:1<79::AID-CNE7>3.0.CO;2-Q"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1136\/jamia.2001.0080443"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2011.0008"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902300402"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90530-X"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.06.005"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsv030"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq237"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22553"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095740"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2011.00069"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.11.030"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90777.2008"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)01001-1"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.09.010"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096146"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02382003"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bht187"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(82)90201-6"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23042"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1944"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.06.028"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23809"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12179"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:26:2:089"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0786-14.2014"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05568.x"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(91)90531-V"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2013.11.001"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.02.014"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.02.056"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1017\/S000712500016180X"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1080\/20008198.2019.1568133"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20688"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12021-014-9258-x"}],"container-title":["Journal of Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjne.12822","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.12822","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jne.12822","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.12822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T08:54:28Z","timestamp":1694076868000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jne.12822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":95,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/jne.12822"],"URL":"https:\/\/doi.org\/10.1111\/jne.12822","archive":["Portico"],"relation":{},"ISSN":["0953-8194","1365-2826"],"issn-type":[{"value":"0953-8194","type":"print"},{"value":"1365-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"2019-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12822"}}