{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:39:14Z","timestamp":1780468754803,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T00:00:00Z","timestamp":1584921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000269","name":"Economic and Social Research Council","doi-asserted-by":"publisher","award":["ES\/K009400\/1"],"award-info":[{"award-number":["ES\/K009400\/1"]}],"id":[{"id":"10.13039\/501100000269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004941","name":"Guy's and St Thomas' NHS Foundation Trust","doi-asserted-by":"publisher","award":["R1405174"],"award-info":[{"award-number":["R1405174"]}],"id":[{"id":"10.13039\/501100004941","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous research has found that exogenous oxytocin administration has the potential to modulate attentional biases in women with anorexia nervosa. Recent work has indicated that attentional biases to food may reinforce the recurrent binge eating behaviour characterising bulimia nervosa and binge eating disorder. To date, however, no study has yet investigated the effect of oxytocin on attentional biases to palatable food in women with bulimia nervosa and binge eating disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present study employed a single\u2010session cross\u2010over design to test the hypothesis that a divided dose of 64\u00a0IU of intranasal oxytocin, administered as one intranasal dose of 40\u00a0IU of oxytocin followed by a top\u2010up of 24\u00a0IU of oxytocin 80\u00a0minutes later, vs placebo administration administered in the same dosing schedule would reduce attentional biases towards food images in a dot probe task. We hypothesised that oxytocin administration would reduce vigilance towards food to a greater degree in women with bulimia nervosa or binge eating disorder vs healthy comparison women. Twenty\u2010five women with bulimia nervosa or binge eating disorder and 27 comparison women without history of an eating disorder were recruited to take part in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In contrast to our hypothesis, there was no main effect of diagnosis on attentional bias to food (fixed effect\u00a0=\u00a05.70, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.363), nor a significant interaction between diagnosis and drug condition (fixed effect =\u221214.80, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.645). There was a main effect of drug condition, such that oxytocin increased vigilance towards food vs neutral images in the dot probe task (fixed effect\u00a0=\u00a010.42, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.044). A correlation analysis revealed that this effect was moderated by attentional bias in the placebo condition, such that greater avoidance of food stimuli in the placebo condition was associated with a greater increase in vigilance induced by oxytocin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings of the present study add to a mixed body of literature investigating the therapeutic effects of oxytocin in women. Future research would benefit from dose\u2010response studies investigating the optimal dose of oxytocin for modulating the attentional processing of palatable food in populations with eating disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jne.12843","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T15:40:22Z","timestamp":1584114022000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A pilot study investigating the influence of oxytocin on attentional bias to food images in women with bulimia nervosa or binge eating disorder"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0216-7432","authenticated-orcid":false,"given":"Monica","family":"Leslie","sequence":"first","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience (IoPPN) King\u2019s College London (KCL) London 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