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Lactational hyperprolactinaemia is associated with a reduced activity of TIDA neurones. However, it remains controversial whether the suckling\u2010induced PRL surge is driven by an additional decrease in dopamine release or by stimulation from a PRL\u2010releasing factor. In the present study, we further investigated the role of dopamine in the PRL response to suckling. Non\u2010lactating (N\u2010Lac), lactating 4\u00a0hour apart from pups (Lac), Lac with pups return and suckling (Lac+S), and post\u2010lactating (P\u2010Lac) rats were evaluated. PRL levels were elevated in Lac rats and increased linearly within 30 minutes of suckling in Lac+S rats. During the rise in PRL levels, dopamine and 3,4\u2010dihydroxyphenylacetic acid (DOPAC) levels in the median eminence (ME) and neurointermediate lobe of the pituitary did not differ between Lac+S and Lac rats. However, dopamine and DOPAC were equally decreased in Lac and Lac+S compared to N\u2010Lac and P\u2010Lac rats. Suckling, in turn, reduced phosphorylation of tyrosine hydroxylase in the ME of Lac+S. Domperidone and bromocriptine were used to block and activate pituitary dopamine D2 receptors, respectively. Domperidone increased PRL secretion in both N\u2010Lac and Lac rats, and suckling elicited a robust surge of PRL over the high basal levels in domperidone\u2010treated Lac+S rats. Conversely, bromocriptine blocked the PRL response to suckling. The findings obtained in the present study provide evidence that dopamine synthesis and release are tonically reduced during lactation, whereas dopamine is still functional with respect to inhibiting PRL secretion. However, there appears to be no further reduction in dopamine release associated with the suckling\u2010induced rise in PRL. Instead, the lower dopaminergic tone during lactation appears to be required to sensitise the pituitary to a suckling\u2010induced PRL\u2010releasing factor.<\/jats:p>","DOI":"10.1111\/jne.12880","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T17:54:52Z","timestamp":1591725292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Reduced dopaminergic tone during lactation is permissive to the hypothalamic stimulus for suckling\u2010induced prolactin release"],"prefix":"10.1111","volume":"32","author":[{"given":"Kaoma S. C.","family":"Silva","sequence":"first","affiliation":[{"name":"Departamento de Fisiologia e Biofisica Instituto de Ciencias Biologicas Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayara S. 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