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However, so far, it is unknown whether oxytocin influences the underlying motivational behaviour towards food. In the present study, we used a food\u2010based approach\u2010avoidance task (AAT) in a randomised, placebo\u2010controlled, double\u2010blind, cross\u2010over design to compare intranasal oxytocin with a placebo. In the AAT, participants pushed or pulled a joystick when images of foods with a high or low craving rating were presented, where differences in response times typically reflect approach and avoidance motivational biases towards positively and negatively valence stimuli, respectively. Thirty\u2010three healthy male participants (age\u00a0=\u00a025.12\u00a0\u00b1\u00a03.51\u00a0years; body mass index\u00a0=\u00a024.25\u00a0\u00b1\u00a02.48\u00a0kg\/m<jats:sup>2<\/jats:sup>) completed the two\u2010session study, one with placebo and the other with oxytocin. We used mixed\u2010effects models to investigate effects of treatment (oxytocin, placebo), response type (approach, avoid) and stimulus (high, low craving). The results showed that both approach and avoid responses tended to be faster for foods higher in craving compared to foods lower in craving. Most importantly, we did not observe any significant effects of oxytocin compared to placebo in motivational behaviour towards food. Our study demonstrates a general response bias towards foods with different craving values, which could have implications for future studies investigating food\u2010related behaviour. We discuss possible explanations for the null effects of oxytocin and suggest further investigation of the relationship between oxytocin, dopamine and food\u2010reward processing.<\/jats:p>","DOI":"10.1111\/jne.12923","type":"journal-article","created":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T04:45:36Z","timestamp":1606020336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Unchanged food approach\u2010avoidance behaviour of healthy men after oxytocin administration"],"prefix":"10.1111","volume":"32","author":[{"given":"Anna","family":"Melkonyan","sequence":"first","affiliation":[{"name":"Department of Decision Neuroscience and Nutrition German Institute of Human Nutrition, (DIfE) Nuthetal Germany"},{"name":"Bernstein Center for Computational Neuroscience Berlin Technische Universit\u00e4t Berlin Berlin 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