{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:47:07Z","timestamp":1789429627563,"version":"build-2803163510"},"reference-count":103,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Infertility associated with insulin resistance is characterised by abnormal hormone secretion by the hypothalamus, pituitary gland and gonads. These endocrine tissues can maintain insulin sensitivity even when tissues such as the muscle and liver become insulin\u2010resistant, resulting in excessive insulin stimulation as hyperinsulinaemia develops. Experiments conducted to determine the role of neuronal insulin signalling in fertility were unable to recapitulate early findings of hypogonadotrophic hypogonadism in mice lacking insulin receptors throughout the brain. Rather, it was eventually shown that astrocytes critically mediate the effects of insulin on puberty timing and adult reproductive function. However, specific roles for neurones and gonadotrophs have been revealed under conditions of hyperinsulinaemia and by ablation of insulin and leptin receptors. The collective picture is one of multiple insulin\u2010responsive inputs to gonadotrophin releasing hormone neurones, with astrocytes being the most important player.<\/jats:p>","DOI":"10.1111\/jne.12930","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T15:56:38Z","timestamp":1612281398000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Role of insulin in the neuroendocrine control of reproduction"],"prefix":"10.1111","volume":"33","author":[{"given":"Maggie C.","family":"Evans","sequence":"first","affiliation":[{"name":"Centre for Neuroendocrinology and Department of Anatomy University of Otago Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer W.","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology University of Toledo Toledo OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6747-8047","authenticated-orcid":false,"given":"Greg M.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Centre for Neuroendocrinology and Department of Anatomy University of Otago Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00475.2004"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.7.8770941"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.9.3419"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00670.2007"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.05.051"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3138-16.2017"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5487.2122"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0457"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms024"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.82.1.3840"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-57-2-356"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.41.10.1257"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.75.2.577"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/13625180802549962"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2010.01.014"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e32833e1264"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2015.12.006"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0956"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.01.010"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15686-y"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.173"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2005.07.002"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0728"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41069"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119995"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.06.010"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-108-4-1441"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2006.02.001"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2011.01.001"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.2741\/s150"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1642-431X(12)60054-0"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000109095"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018-00691"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-127-6-3234"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.49.030187.002003"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1159\/000083140"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3328-05.2005"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1159\/000095549"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.08.057"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2008.08.013"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0337"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.2337\/db05-1584"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12166"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-2056"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121974"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2274"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.17925\/EE.2019.15.2.83"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120775"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1406"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1374"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.1.395"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.11.7139"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-24-08578.2003"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2011.02145.x"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2278-13.2013"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1412"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1093"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod46.6.1151"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1470"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1054\/npep.2002.0890"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2739-05.2005"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.05.004"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1621065114"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1120501109"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(95)00070-G"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-126-3-1771"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1159\/000127245"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.08.071"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.04.001"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2847"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3118-09.2010"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23350"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.03.002"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.4.8089"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2006.05.012"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.5.1237"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.8.2471"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2012.02351.x"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1657-07.2007"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2007.01643.x"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0401"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.10.2521"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(03)00560-X"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.110122"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.7.2056"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-5-54"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/77660"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.22.12737"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02440"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324888"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59660"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2007.01576.x"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2008.01712.x"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-1434"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-1435"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000189"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.07.028"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(05)47003-5"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2020.110996"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01892.x"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.202051"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12330"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-16-0212"}],"container-title":["Journal of Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.12930","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jne.12930","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.12930","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T23:59:43Z","timestamp":1693526383000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jne.12930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":103,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1111\/jne.12930"],"URL":"https:\/\/doi.org\/10.1111\/jne.12930","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JNE.12930\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.12930\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.12930\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.12930\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.12930\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.12930\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.12930\/v2\/review1","asserted-by":"object"}]},"ISSN":["0953-8194","1365-2826"],"issn-type":[{"value":"0953-8194","type":"print"},{"value":"1365-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"2020-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12930"}}