{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:49:00Z","timestamp":1784735340586,"version":"3.55.0"},"reference-count":63,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:00:00Z","timestamp":1619395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009066","name":"Instituto Carlos Slim de la Salud","doi-asserted-by":"publisher","award":["FIS PI19\/00166"],"award-info":[{"award-number":["FIS PI19\/00166"]}],"id":[{"id":"10.13039\/501100009066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Puberty is a crucial biological process normally occurring at a specific time during the lifespan, during which sexual and somatic maturation are completed, and reproductive capacity is reached. Pubertal timing is not only determined by genetics, but also by endogenous and environmental cues, including nutritional and metabolic signals. During the last decade, we have learned much regarding the essential roles of kisspeptins and the neuropeptide pathways that converge on these neurones to modulate kisspeptin signalling, as well as neurokinin B and dynorphin, the co\u2010transmitters of Kiss1 neurones in the arcuate nucleus, and the effects of melanocortins on puberty. Indeed, melanocortins are involved in transmitting the regulatory actions of metabolic cues on pubertal maturation. Intracellular metabolic sensors, such as the AMP\u2010activated protein kinase and the fuel\u2010sensing deacetylase SIRT1, have been shown to contribute to puberty. Further understanding of these signals and regulatory circuits will help uncover the intimacies of the central control of puberty, as well as how alterations in metabolic status, ranging from undernutrition to obesity, affect the pubertal process. Precocious puberty is rare and has a clear female predominance. Central precocious puberty (CPP) is diagnosed when premature activation of the hypothalamic\u2010pituitary axis occurs. Its causes are heterogeneous, with alterations of the central nervous system being of special interest, and with environmental factors also playing a role in some cases. During the last decade, several mutations in different genes (including\n                    <jats:italic>KISS1, KISS1R, MKRN3<\/jats:italic>\n                    and\n                    <jats:italic>DLK1<\/jats:italic>\n                    ) that cause CPP have been discovered. Loss\u2010of\u2010function mutations in\n                    <jats:italic>MKRN3<\/jats:italic>\n                    are the most common monogenic cause of CPP known to date. Here, we review and update what is known regarding the genotype\u2010phenotype relationship in patients with CPP.\n                  <\/jats:p>","DOI":"10.1111\/jne.12979","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T03:19:05Z","timestamp":1619493545000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Precocious sexual maturation: Unravelling the mechanisms of pubertal onset through clinical observations"],"prefix":"10.1111","volume":"34","author":[{"given":"Leandro","family":"Soriano\u2010Guill\u00e9n","sequence":"first","affiliation":[{"name":"Department of Pediatrics Universidad Aut\u00f3noma de Madrid  Madrid Spain"},{"name":"Department of Pediatrics Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz  Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Fundaci\u00f3n Jim\u00e9nez D\u00edaz  Madrid 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Medicine, Discipline Endocrinology and Metabolism Faculty of Medicine Clinicas Hospital University of Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C.","family":"Latronico","sequence":"additional","affiliation":[{"name":"Laboratory of Hormones and Molecular Genetics LIM42 Developmental Endocrinology Unit Department of Internal Medicine, Discipline Endocrinology and Metabolism Faculty of Medicine Clinicas Hospital University of Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5826-0276","authenticated-orcid":false,"given":"Jes\u00fas","family":"Argente","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Universidad Aut\u00f3noma de Madrid  Madrid Spain"},{"name":"Department of Pediatrics &amp; Pediatric Endocrinology Hospital Infantil Universitario Ni\u00f1o Jes\u00fas Instituto de Investigaci\u00f3n La Princesa  Madrid 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