{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:16:24Z","timestamp":1791616584945,"version":"4.3.4"},"reference-count":67,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T00:00:00Z","timestamp":1625356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/S000224\/1"],"award-info":[{"award-number":["BB\/S000224\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/S021035\/1"],"award-info":[{"award-number":["BB\/S021035\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GR 3619\/13\u20101"],"award-info":[{"award-number":["GR 3619\/13\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GR 3619\/15\u20101"],"award-info":[{"award-number":["GR 3619\/15\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GR 3619\/16\u20101"],"award-info":[{"award-number":["GR 3619\/16\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GR 3619\/8\u20101"],"award-info":[{"award-number":["GR 3619\/8\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1158\/2"],"award-info":[{"award-number":["SFB 1158\/2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Classically, hypothalamic neuroendocrine cells that synthesise oxytocin and vasopressin were categorised in two major cell types: the magnocellular and parvocellular neurones. It was assumed that magnocellular neurones project exclusively to the pituitary gland where they release oxytocin and vasopressin into the systemic circulation. The parvocellular neurones, on the other hand, project within the brain to regulate discrete brain circuitries and behaviours. Within the last few years, it has become evident that the classical view of these projections is outdated. It is now clear that oxytocin and vasopressin in the brain are released extrasynaptically from dendrites and from varicosities in distant axons. The peptides act principally to modulate information transfer through conventional synapses (such as glutamate synapses) by actions at respective receptors that may be preferentially localised to synaptic regions (on either side of the synapse) to alter the \u2018gain\u2019 of conventional synapses.<\/jats:p>","DOI":"10.1111\/jne.13004","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T00:31:45Z","timestamp":1623976305000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["The multiple faces of the oxytocin and vasopressin systems in the brain"],"prefix":"10.1111","volume":"33","author":[{"given":"Valery","family":"Grinevich","sequence":"first","affiliation":[{"name":"Department of Neuropeptide Research in Psychiatry Central Institute of Mental Health University of Heidelberg Mannheim Germany"},{"name":"Centre for Neuroinflammation and Cardiometabolic Diseases Georgia State University Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9983-4950","authenticated-orcid":false,"given":"Mike","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Centre for Discovery Brain Sciences University of Edinburgh Edinburgh UK"},{"name":"Centre for Neuroendocrinology, Department of Immunology University of Pretoria Pretoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12549"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.06.030183.001413"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000123111"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp021001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(90)90017-B"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4462"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2011890117"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.10.032"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.11.030"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2409-15.2016"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.02.044"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.04.070"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201023064\u20105"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00604.2003"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00839.2001"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91485-X"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(02)39024-1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00035"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e31829f57df"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.01.041"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.04.029"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-0674-y"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)64435-0"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12831"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0830"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08826"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.196139"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP274025"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2015.00130"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-86630-3_7"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(93)90035-Q"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2002.8022"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2001.00684.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2003.00967.x"},{"issue":"1","key":"e_1_2_7_36_1","first-page":"74","article-title":"Increased colocalization of corticotropin\u2010releasing factor and arginine vasopressin in paraventricular neurones of the hypothalamus in lactating rats: evidence from immunotargeted lesions and immunohistochemistry","volume":"13","author":"Walker CD","year":"2001","journal-title":"J Neuroendocrinol"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.10.002"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092310406"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.09.089"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2008.01719.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1845"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2004.05.001"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00822"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000123"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.04.025"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01892-4"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.175810"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00218.2011"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2017.08.005"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.3.1197"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0680209"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.1.180"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1020063"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00248916"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1989.sp017442"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1984.sp015302"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021783"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12518"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan4994"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.07.005"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00031"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010021\u201000800\u20100"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003187"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2017-03068"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.22170"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.2.573"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)00403-2"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0151-z"}],"container-title":["Journal of Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.13004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jne.13004","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.13004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:17:12Z","timestamp":1693210632000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jne.13004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,4]]},"references-count":67,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/jne.13004"],"URL":"https:\/\/doi.org\/10.1111\/jne.13004","archive":["Portico"],"relation":{},"ISSN":["0953-8194","1365-2826"],"issn-type":[{"value":"0953-8194","type":"print"},{"value":"1365-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,4]]},"assertion":[{"value":"2021-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13004"}}