{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T05:29:05Z","timestamp":1781760545455,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The COVID\u201019 pandemic has added another layer of complexity to the fears of patients with neuroendocrine tumors (NETs). Little is known regarding the psychological impact of the COVID\u201019 outbreak on patients with gastroenteropancreatic or bronchopulmonary (BP) NETs. We longitudinally surveyed the mental symptoms and concerns of NET patients during the plateau phase of the first (W1) and second epidemic waves (W2) in Italy. Seven specific constructs (depression, anxiety, stress, health\u2010related quality of life, NET\u2010related quality of life, patient\u2013physician relationship, psychological distress) were investigated using validated screening instruments, including DASS\u201021, EORTC QLQ\u2010C30, EORTC QLQ GI.NET21, PDRQ9 and IES\u2010R. We enrolled 197 patients (98\u00a0males) with a median age of 62\u00a0years. The majority of the patients had G1\/G2 neoplasms. Some 38% of the patients were on active treatment. At W1, the prevalence of depression, anxiety and stress was 32%, 36% and 26% respectively. The frequency of depression and anxiety increased to 38% and 41% at W2, whereas no modifications were recorded in the frequency of stress. Poor educational status was associated with higher levels of anxiety at both W1 (odds ratio [OR]\u00a0=\u00a01.33\u00a0\u00b1\u00a00.22;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.07) and W2 (OR\u00a0=\u00a01.45\u00a0\u00b1\u00a00.26;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.03). Notably, post\u2010traumatic stress symptoms were observed in the 58% of the patients, and both single marital status (OR\u00a0=\u00a00.16, 95% confidence interval [CI]\u00a0=\u00a00.06\u20130.48;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.0009) and low levels of formal education (OR\u00a0=\u00a00.47, 95% CI\u00a0=\u00a00.23\u20130.99;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.05) predicted their occurrence. No significant deteriorations of health\u2010related quality of life domains were observed from W1 to W2. High patient care satisfaction was documented despite the changes in health systems resource allocation. NET patients have an increased risk of developing post\u2010traumatic stress symptoms as result of the COVID\u201019 pandemic. Specific screening measures and psychological interventions should be implemented in NET clinics to prevent, recognize and treat mental distress in this vulnerable population.\n                  <\/jats:p>","DOI":"10.1111\/jne.13041","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T09:05:51Z","timestamp":1632128751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The psychological impact of COVID\u201019 pandemic on patients with neuroendocrine tumors: Between resilience and vulnerability"],"prefix":"10.1111","volume":"33","author":[{"given":"Eleonora","family":"Lauricella","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology University of Bari \u201cAldo Moro\u201d Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Cives","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology University of Bari \u201cAldo Moro\u201d Bari Italy"},{"name":"National Cancer Institute IRCCS Istituto Tumori Giovanni Paolo II Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Bracigliano","sequence":"additional","affiliation":[{"name":"Istituto Nazionale Tumori IRCCS Fondazione \u201cG. Pascale\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ottavia","family":"Clemente","sequence":"additional","affiliation":[{"name":"Istituto Nazionale Tumori IRCCS Fondazione \u201cG. Pascale\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Felici","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology University of Bari \u201cAldo Moro\u201d Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Lippolis","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology University of Bari \u201cAldo Moro\u201d Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brunella","family":"Amoruso","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology University of Bari \u201cAldo Moro\u201d Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Pelle'","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology University of Bari \u201cAldo Moro\u201d Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Mandriani","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology University of Bari \u201cAldo Moro\u201d Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Esposto","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology University of Bari \u201cAldo Moro\u201d Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cira","family":"Forte","sequence":"additional","affiliation":[{"name":"Istituto Nazionale Tumori IRCCS Fondazione \u201cG. Pascale\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Perri","sequence":"additional","affiliation":[{"name":"Istituto Nazionale Tumori IRCCS Fondazione \u201cG. Pascale\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camillo","family":"Porta","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology University of Bari \u201cAldo Moro\u201d Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Tafuto","sequence":"additional","affiliation":[{"name":"Istituto Nazionale Tumori IRCCS Fondazione \u201cG. Pascale\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30251-8"},{"key":"e_1_2_9_4_1","unstructured":"World Health Organization.Coronavirus disease (COVID\u201019) outbreak.https:\/\/www.who.int.Home\/Diseases\/Coronavirus\u201019. Accessed 11 March 2020."},{"issue":"9","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1136\/jech-2020-214475","article-title":"Are we all in this together? Longitudinal assessment of cumulative adversities by socioeconomic position in the first 3 weeks of lockdown in the UK","volume":"74","author":"Wright L","year":"2020","journal-title":"J Epidemiol Community Health"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30482-X"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30308-4"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329172000241X"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30096-6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21493"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3_34"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3_36"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3_31"},{"key":"e_1_2_9_14_1","first-page":"16","volume-title":"WHO Classification of Tumours: Digestive System Tumours","author":"Klimstra DS","year":"2019"},{"key":"e_1_2_9_15_1","volume-title":"WHO Classification of Tumours of the Lung, Pleura, Thymus, and Heart","author":"Travis WD","year":"2015"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(94)00075-U"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.365"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.560"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2003.08.010"},{"key":"e_1_2_9_20_1","first-page":"399","volume-title":"Assessing Psychological Trauma and PTSD","author":"Weiss DS","year":"1997"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.78.5865"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.111.087932"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01393-4"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i6.671"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197307000-00013"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-9861.2004.tb00093.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-018-4166-5"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-200405000-00022"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.5067"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860152703445"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-020-02564-2"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2020.616723"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm-21-745"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-021-00592-3"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30460-8"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-8-347"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-00950-y"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.559701"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01270"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5434"},{"key":"e_1_2_9_41_1","first-page":"1","article-title":"The impact of the COVID\u201019 pandemic on the quality of life of head and neck cancer survivors","author":"Gallo O","year":"2021","journal-title":"Support Care Cancer"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2020.1830169"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3950"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.6093"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000055362"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2354.2002.00293.x"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2354.2003.00322.x"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-6712.2008.00596.x"}],"container-title":["Journal of Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.13041","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jne.13041","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.13041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T11:55:34Z","timestamp":1725796534000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jne.13041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":47,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1111\/jne.13041"],"URL":"https:\/\/doi.org\/10.1111\/jne.13041","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JNE.13041\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13041\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13041\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13041\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13041\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13041\/v2\/response1","asserted-by":"object"}]},"ISSN":["0953-8194","1365-2826"],"issn-type":[{"value":"0953-8194","type":"print"},{"value":"1365-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"2021-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13041"}}