{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:12:48Z","timestamp":1790809968112,"version":"4.1.0"},"reference-count":84,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN\u2010143337"],"award-info":[{"award-number":["FDN\u2010143337"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Magnocellular neurosecretory cells that release vasopressin (MNC\n                    <jats:sup>VP<\/jats:sup>\n                    ) from axon terminals in the neurohypophysis display a unique pattern of action potential firing termed phasic firing. Under basal conditions, only a small proportion of MNC\n                    <jats:sup>VP<\/jats:sup>\n                    display spontaneous phasic firing. However, acute and chronic conditions that stimulate vasopressin release, such as hemorrhage and dehydration, greatly enhance the number of MNC\n                    <jats:sup>VP<\/jats:sup>\n                    that fire phasically. Phasic firing optimizes VP neurosecretion at axon terminals by allowing action potential broadening to promote calcium\u2010dependent frequency\u2010facilitation, at the same time as preventing the secretory fatigue caused by spike inactivation that occurs during prolonged continuous stimulation. This review provides an update on our mechanistic understanding of these processes and highlights important gaps in our knowledge that must be addressed in future experiments.\n                  <\/jats:p>","DOI":"10.1111\/jne.13048","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T19:44:11Z","timestamp":1633463051000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Mechanism and function of phasic firing in vasopressin\u2010releasing magnocellular neurosecretory cells"],"prefix":"10.1111","volume":"33","author":[{"given":"Zahra S.","family":"Thirouin","sequence":"first","affiliation":[{"name":"Research Institute of the McGill University Health Centre Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1594-742X","authenticated-orcid":false,"given":"Charles W.","family":"Bourque","sequence":"additional","affiliation":[{"name":"Research Institute of the McGill University Health Centre Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1977.sp011999"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(82)90044-6"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90730-8"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/258080b0"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0570477"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1971.sp009430"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(72)90538-0"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(71)90580-4"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(70)90129-9"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.12.6684"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.185.4150.535"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1973.sp010285"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00238799"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000123336"},{"key":"e_1_2_12_16_1","article-title":"Activity patterns and osmosensitivity of rat supraoptic neurones in perfused hypothalamic explants","volume":"349631","author":"Bourque CW","year":"1984","journal-title":"J Physiol"},{"key":"e_1_2_12_17_1","article-title":"Electrophysiology of guinea\u2010pig supraoptic neurones: role of a hyperpolarization\u2010activated cation current in phasic firing","volume":"460407","author":"Erickson KR","year":"1993","journal-title":"J Physiol"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)00420-2"},{"key":"e_1_2_12_19_1","first-page":"458667","article-title":"NMDA receptor\u2010mediated rhythmic bursting activity in rat supraoptic nucleus neurones in vitro","author":"Hu B","year":"1992","journal-title":"Jphysiol"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.275602"},{"issue":"3","key":"e_1_2_12_21_1","first-page":"R569","article-title":"Alpha 1\u2010adrenergic receptor activation depolarizes rat supraoptic neurosecretory neurons in vitro","volume":"251","author":"Randle JC","year":"1986","journal-title":"Am J Physiol"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1974.sp010722"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0570459"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1977.0046"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1966.sp007820"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1971.sp009499"},{"key":"e_1_2_12_27_1","article-title":"Paired recordings from supraoptic and paraventricular oxytocin cells in suckled rats: recruitment and synchronization","volume":"377369","author":"Belin V","year":"1986","journal-title":"J Physiol"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/258082a0"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(83)90509-8"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91392-2"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020053"},{"issue":"4","key":"e_1_2_12_32_1","first-page":"291","article-title":"Morphological and electrophysiological classification of hypothalamic supraoptic neurons","volume":"47","author":"Armstrong WE","year":"1995","journal-title":"ProgNeurobiol"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(74)90237-6"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0560091"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.180232"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1979.sp012781"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/344449a0"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(92)81812-X"},{"key":"e_1_2_12_39_1","article-title":"The role of patterned burst and interburst interval on the excitation\u2010coupling mechanism in the isolated rat neural lobe","volume":"36945","author":"Cazalis M","year":"1985","journal-title":"J Physiol"},{"key":"e_1_2_12_40_1","article-title":"Optimizing release from peptide hormone secretory nerve terminals","volume":"13951","author":"Bicknell RJ","year":"1988","journal-title":"J Exp Biol"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1159\/000123248"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000124582"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)64400-3"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1159\/000123418"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(91)90180-3"},{"key":"e_1_2_12_46_1","first-page":"421247","article-title":"Intraterminal recordings from the rat neurohypophysis in vitro","author":"Bourque CW","year":"1990","journal-title":"Jphysiol"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.2.380"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp020609"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-017-2051-6"},{"key":"e_1_2_12_50_1","article-title":"Multiple roles of Gi\/o protein\u2010coupled receptors in control of action potential secretion coupling in pituitary lactotrophs","volume":"1152174","author":"Stojilkovic SS","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8380942"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp020608"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90920-X"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90882-X"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2948-09.2010"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1983.sp002742"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816X.2004.03408.x"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2005.11.005"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1984.51.3.552"},{"key":"e_1_2_12_60_1","article-title":"Properties of supraoptic magnocellular neurones isolated from the adult rat","volume":"455291","author":"Oliet SH","year":"1992","journal-title":"J Physiol"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(76)90055-0"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6879204"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(86)90464-7"},{"issue":"3","key":"e_1_2_12_64_1","first-page":"183","article-title":"Electrophysiology of mammalian magnocellular vasopressin and oxytocin neurosecretory neurons","volume":"11","author":"Bourque CW","year":"1990","journal-title":"Front Neuroendocrinol"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.063818"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00062.2006"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0351236"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1985.54.6.1375"},{"key":"e_1_2_12_69_1","article-title":"Intrinsic inhibition in magnocellular neuroendocrine cells of rat hypothalamus","volume":"353171","author":"Andrew RD","year":"1984","journal-title":"J Physiol"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(87)90127-3"},{"issue":"2","key":"e_1_2_12_71_1","first-page":"389","article-title":"Activity dependence and functional role of the apamin\u2010sensitive K+ current in rat supraoptic neurones in vitro","volume":"494","author":"Kirkpatrick K","year":"1996","journal-title":"Jphysiol"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.493bb.x"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2004.01204.x"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP278910"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1240-04.2004"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4203-03.2004"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1027424128972"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10827-007-0024-z"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biosystems.2013.03.010"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003187"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002740"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12662"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1997.095bc.x"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.032094"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1044"}],"container-title":["Journal of Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.13048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jne.13048","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.13048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:17:02Z","timestamp":1693210622000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jne.13048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,20]]},"references-count":84,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/jne.13048"],"URL":"https:\/\/doi.org\/10.1111\/jne.13048","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JNE.13048\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13048\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13048\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13048\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13048\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0953-8194","1365-2826"],"issn-type":[{"value":"0953-8194","type":"print"},{"value":"1365-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,20]]},"assertion":[{"value":"2021-07-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13048"}}