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Affiliative tactile stimuli in early life facilitate the development of social and emotional behaviour, whereas early\u2010life adverse stimuli have been shown to increase the risk of various diseases in later life. On the other hand, oxytocin has been shown to have organizational actions during early\u2010life stages. However, the detailed mechanisms of the effects of early\u2010life experience and oxytocin remain unclear. Here, we review the effects of affiliative tactile stimuli during the neonatal period and neonatal oxytocin treatment on the activity of the oxytocin\u2013oxytocin receptor system and social or emotional behaviour in adulthood. Both affiliative tactile stimuli and early\u2010life adverse stimuli in the neonatal period acutely activate the oxytocin\u2013oxytocin receptor system in the brain but modulate social behaviour and anxiety\u2010related behaviour apparently in an opposite direction in adulthood. Accumulating evidence suggests that affiliative tactile stimuli and exogenous application of oxytocin in early\u2010life stages induce higher activity of the oxytocin\u2013oxytocin receptor system in adulthood, although the effects are dependent on experimental procedures, sex, dosages and brain regions examined. On the other hand, early\u2010life stressful stimuli appear to induce reduced activity of the oxytocin\u2013oxytocin receptor system, possibly leading to adverse actions in adulthood. It is possible that activation of a specific oxytocin system can induce beneficial actions against early\u2010life maltreatments and thus could be used for the treatment of developmental psychiatric disorders.<\/jats:p>","DOI":"10.1111\/jne.13049","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T09:55:25Z","timestamp":1633514125000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["The oxytocin system and early\u2010life experience\u2010dependent plastic changes"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5666-9035","authenticated-orcid":false,"given":"Tatsushi","family":"Onaka","sequence":"first","affiliation":[{"name":"Division of Brain and Neurophysiology Department of Physiology Jichi Medical University Tochigi 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