{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:51:55Z","timestamp":1772160715143,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The incidence of duodenal neuroendocrine neoplasms has risen over the past decades as a result of the wide availability of endoscopy and associated expertise. Although it is considered that tumour size greater than 10\u00a0mm, higher tumour grade and\/or location in relation to the ampulla of Vater represent the main risk factors for local or distant metastases, we describe two cases of well differentiated grade 1 and grade 2 neuroendocrine tumours, which measured &lt;\u00a010\u00a0mm at the time of diagnosis but had an aggressive course during follow\u2010up. Furthermore, we also summarise the available therapeutic strategies for the management of small, low grade, non\u2010functioning, non\u2010ampullary duodenal neuroendocrine neoplasms.<\/jats:p>","DOI":"10.1111\/jne.13067","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T03:44:06Z","timestamp":1637811846000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Duodenal neuroendocrine neoplasms with unexpectedly aggressive behaviour: Challenging the \u201cwatch and wait\u201d approach"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5237-2207","authenticated-orcid":false,"given":"Gowri M.","family":"Ratnayake","sequence":"first","affiliation":[{"name":"Neuroendocrine Tumour Unit ENETS Centre of Excellence Royal Free Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj","family":"Srirajaskanthan","sequence":"additional","affiliation":[{"name":"Neuroendocrine Tumour Unit ENETS Centre of Excellence Department of Gastroenterology Institute of Liver Studies Kings College Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TuVinh","family":"Luong","sequence":"additional","affiliation":[{"name":"Neuroendocrine Tumour Unit ENETS Centre of Excellence Royal Free Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gopinath","family":"Gnanasegaran","sequence":"additional","affiliation":[{"name":"Neuroendocrine Tumour Unit ENETS Centre of Excellence Royal Free Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Toumpanakis","sequence":"additional","affiliation":[{"name":"Neuroendocrine Tumour Unit ENETS Centre of Excellence Royal Free Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335595"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2015.03.042"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000511613"},{"issue":"7","key":"e_1_2_8_5_1","first-page":"700","article-title":"Carcinoid tumors of the duodenum. 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