{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T18:50:55Z","timestamp":1788115855410,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T00:00:00Z","timestamp":1644796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In recent years the WHO classification of neuroendocrine neoplasms (NEN) has evolved. Nomenclature as well as thresholds for grading have changed leading to potential confusion and lack of comparability of tumour reports. Therefore, the European Neuroendocrine Tumour Society (ENETS) has set\u2010up an interdisciplinary working group to develop templates for a pathology data set for standardised reporting of NEN. Experts of various disciplines, members of the ENETS Advisory Board, formed a taskforce that discussed and decided on the structure, content and the number of templates needed for reporting the most common NEN. The selection of the required items was based on the WHO classification of digestive system tumours, the WHO classification of tumours of the lung and mediastinum and on \u201cENETS standard of care\u201d reports. The final proposal of the working group was approved by the ENETS Advisory Board. Templates for synoptic reporting were created for the seven most common NEN primary sites, that is, stomach, duodenum, jejunum\u2010ileum, appendix, colon\u2010rectum, pancreas, lung and mediastinum. In addition, a general template for reporting biopsies was designed. The templates allow the recording of the essential items on differentiation, proliferation (Ki\u201067 and mitosis), neuroendocrine features (positivity for chromogranin A and synaptophysin) and stage as well as several optional markers especially helpful for the distinction of neuroendocrine tumours (NET) from neuroendocrine carcinomas (NEC). In summary, this paper presents the content and development of synoptic reports for most sites of NEN by a multidisciplinary team of international experts in the field, which could help to improve unambiguous reporting of NEN.<\/jats:p>","DOI":"10.1111\/jne.13100","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T20:39:03Z","timestamp":1643315943000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["ENETS standardized (synoptic) reporting for neuroendocrine tumour pathology"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0435-9494","authenticated-orcid":false,"given":"Marie\u2010Louise F.","family":"van Velthuysen","sequence":"first","affiliation":[{"name":"Department Pathology Erasmus MC  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6316-1210","authenticated-orcid":false,"given":"Anne","family":"Couvelard","sequence":"additional","affiliation":[{"name":"Service de Pathologie H\u00f4pital Bichat AP\u2010HP et Universit\u00e9 de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2996-4404","authenticated-orcid":false,"given":"Guido","family":"Rindi","sequence":"additional","affiliation":[{"name":"Section of Anatomic Pathology Department of Life Sciences and Public Health Universit\u00e0 Cattolica del Sacro Cuore  Roma Italia"},{"name":"Unit of Anatomic Pathology Department of Woman and Child Health and Public Health Fondazione Policlinico Universitario A. Gemelli IRCCS  Roma Italia"},{"name":"Roma European Neuroendocrine Tumor Society (ENETS) Center of Excellence  Roma Italia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6869-0704","authenticated-orcid":false,"given":"Nicola","family":"Fazio","sequence":"additional","affiliation":[{"name":"Division of gastrointestinal medical oncology and neuroendocrine tumors European Institute of Oncology (IEO) IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"H\u00f6rsch","sequence":"additional","affiliation":[{"name":"CA Gastroenterologie Zentralklinik Bad Berka GmbH  Bad Berka Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3029-6071","authenticated-orcid":false,"given":"Els J.","family":"Nieveen van Dijkum","sequence":"additional","affiliation":[{"name":"Department of Surgery Cancer Centre Amsterdam Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6688-086X","authenticated-orcid":false,"given":"G\u00fcnter","family":"Kl\u00f6ppel","sequence":"additional","affiliation":[{"name":"Department of Pathology Consultation Center for Pancreatic and Endocrine Tumors, TU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6819-6092","authenticated-orcid":false,"given":"Aurel","family":"Perren","sequence":"additional","affiliation":[{"name":"Institute of Pathology University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-016-1935-8"},{"issue":"4","key":"e_1_2_9_3_1","first-page":"253","article-title":"Standardization of the surgical pathology report: formats, templates, and synoptic reports","volume":"11","author":"Leslie KO","year":"1994","journal-title":"Semin Diagn Pathol"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-015-1834-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000457956"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-006-0250-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-007-0452-1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335600"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13975"},{"key":"e_1_2_9_10_1","unstructured":"LloydRV OsamuraRY KloeppelG RosaiG. 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