{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:45:02Z","timestamp":1791571502868,"version":"4.3.4"},"reference-count":174,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["5I01BX004102"],"award-info":[{"award-number":["5I01BX004102"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01DK115976"],"award-info":[{"award-number":["5R01DK115976"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1K01DK118000"],"award-info":[{"award-number":["1K01DK118000"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001509","name":"Royal Society Te Ap\u0101rangi","doi-asserted-by":"publisher","award":["1203"],"award-info":[{"award-number":["1203"]}],"id":[{"id":"10.13039\/501100001509","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The neuropeptide oxytocin (OT) has emerged as an important anorexigen in the regulation of food intake and energy balance. It has been shown that the release of OT and activation of hypothalamic OT neurons coincide with food ingestion. Its effects on feeding have largely been attributed to limiting meal size through interactions in key regulatory brain regions governing the homeostatic control of food intake such as the hypothalamus and hindbrain in addition to key feeding reward areas such as the nucleus accumbens and ventral tegmental area. Furthermore, the magnitude of an anorexigenic response to OT and feeding\u2010related activation of the brain OT circuit are modified by the composition and flavor of a diet, as well as by a social context in which a meal is consumed. OT is particularly effective in reducing consumption of carbohydrates and sweet tastants. Pharmacologic, genetic, and pair\u2010feeding studies indicate that OT\u2010elicited weight loss cannot be fully explained by reductions of food intake and that the overall impact of OT on energy balance is also partly a result of OT\u2010elicited changes in lipolysis, energy expenditure, and glucose regulation. Peripheral administration of OT mimics many of its effects when it is given into the central nervous system, raising the questions of whether and to what extent circulating OT acts through peripheral OT receptors to regulate energy balance. Although OT has been found to elicit weight loss in female mice, recent studies have indicated that sex and estrous cycle may impact oxytocinergic modulation of food intake. Despite the overall promising basic research data, attempts to use OT in the clinical setting to combat obesity and overeating have generated somewhat mixed results. The focus of this mini\u2010review is to briefly summarize the role of OT in feeding and metabolism, address gaps and inconsistencies in our knowledge, and discuss some of the limitations to the potential use of chronic OT that should help guide future research on OT as a tailor\u2010made anti\u2010obesity therapeutic.<\/jats:p>","DOI":"10.1111\/jne.13106","type":"journal-article","created":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T09:43:58Z","timestamp":1644659038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Oxytocin as a potential pharmacological tool to combat obesity"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2846-0485","authenticated-orcid":false,"given":"Pawel K.","family":"Olszewski","sequence":"first","affiliation":[{"name":"Faculty of Science and Engineering University of Waikato  Waikato New Zealand"},{"name":"Department of Food Science and Nutrition College of Food, Agricultural and Natural Resource Sciences University of Minnesota  St Paul Minnesota USA"},{"name":"Department of Integrative Biology and Physiology Medical School University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7483-031X","authenticated-orcid":false,"given":"Emily E.","family":"Noble","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3037-2756","authenticated-orcid":false,"given":"Luis","family":"Paiva","sequence":"additional","affiliation":[{"name":"Instituto de Ciencia Animal Facultad de Ciencias Veterinarias Universidad Austral de Chile  Valdivia Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0702-9538","authenticated-orcid":false,"given":"Yoichi","family":"Ueta","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Medicine University of Occupational and Environmental Health  Kitakyushu Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7587-0380","authenticated-orcid":false,"given":"James\u00a0E.","family":"Blevins","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs Medical Center VA Puget Sound Health Care System Office of Research and Development Medical Research Service  Seattle Washington USA"},{"name":"Division of Metabolism, Endocrinology and Nutrition Department of Medicine University of Washington School of Medicine  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(89)90082-X"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(90)90234-U"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3715453"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(88)90154-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(81)90366-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(86)90071-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(85)90255-0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-11-0272"},{"issue":"1","key":"e_1_2_8_10_1","first-page":"R9","article-title":"Hypertonic NaCl inhibits gastric motility and food intake in rats with lesions in the rostral AV3V region","volume":"263","author":"Flanagan LM","year":"1992","journal-title":"Am J Physiol"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(98)00147-3"},{"issue":"4","key":"e_1_2_8_12_1","first-page":"R661","article-title":"Cholecystokinin and gastric distension activate oxytocinergic cells in rat hypothalamus","volume":"253","author":"Renaud LP","year":"1987","journal-title":"Am J Physiol"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2016-1640"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.08.003"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0151"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12019"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1668-09.2009"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2017-00200"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0295"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2008-0067"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059625"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3412-08.2008"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000001005"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.10.008"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00604.2003"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-01-00559.1998"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045167"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12016"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.2.7295"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.281.2.R673"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.5.6717"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00042.2005"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-09-0009"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2008.07.009"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0720010.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2007.01.011"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11270"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-013-9260-x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12805"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00220.2015"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(91)90176-P"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4442"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00297"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.06.003"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2018.05.028"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12518"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan4994"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24116"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00201.2020"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12381"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2013.03.026"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.226"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-019-0489-7"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2021.113464"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00441.2014"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(97)00021-8"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00228.2007"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00826.2006"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.115"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21069"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0663"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2018.08.003"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2019.112704"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2020.104855"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20963-4"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.1991.tb00264.x"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2005.05.002"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13820.x"},{"issue":"6","key":"e_1_2_8_69_1","first-page":"R1626","article-title":"Stimulation of oxytocin release within the supraoptic nucleus and into blood by CCK\u20108","volume":"267","author":"Neumann I","year":"1994","journal-title":"Am J Physiol"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)00609-9"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-1440"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.11.021"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1435"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000000201"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00520.2013"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12841"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(97)00231-3"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-64-1-190"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(88)90139-4"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28816-w"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-0006"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12290"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2016.02.005"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.02.027"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(93)90290-R"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12150"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2006.09.005"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12576-017-0550-z"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2008-0024"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66378-7"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.151092"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3319"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.04.033"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1198"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-0682"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2020.05.001"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0106-75"},{"key":"e_1_2_8_99_1","first-page":"1","article-title":"Prevalence of obesity and severe obesity among adults: United States, 2017\u20132018","volume":"360","author":"Hales CM","year":"2020","journal-title":"NCHS Data Brief"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.7326\/ACPJ202107200-080"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0234"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/osp4.156"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.75"},{"key":"e_1_2_8_104_1","first-page":"209","article-title":"Establishing behavioral and physiological functions of central oxytocin: insights from studies of oxytocin and ingestive behaviors","volume":"395","author":"Verbalis JG","year":"1995","journal-title":"Adv Exp Med Biol"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(00)00311-0"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0080238"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2011.07.001"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3327-12.2012"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-02080"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21069"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061477"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22106-1"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.07.011"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.009621"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2010.08.002"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808718"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2016.02.009"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025565"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09318-7"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100408"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00296.2011"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00169.2017"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.12.036"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00196.2011"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00294.2020"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.725912"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00845-X"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2011.330"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.2337\/db18-0462"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.12.009"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2496"},{"issue":"4","key":"e_1_2_8_132_1","first-page":"R1371","article-title":"Effect of CL\u2010316,243, a thermogenic beta 3\u2010agonist, on energy balance and brown and white adipose tissues in rats","volume":"266","author":"Himms\u2010Hagen J","year":"1994","journal-title":"Am J Physiol"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.2337\/db18-0462"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2017.04.008"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13516"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.952"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI131126"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13181-012-0213-7"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/298161a0"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.1159\/000125958"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1702725114"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21124"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-13-0284"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25977"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.05.062"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2010.184"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2009.00654.x"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2017.02.007"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2016.10.005"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12923"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12584"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147737"},{"key":"e_1_2_8_153_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12627"},{"key":"e_1_2_8_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2011.02.015"},{"key":"e_1_2_8_155_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2012.0048"},{"key":"e_1_2_8_156_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.726411"},{"key":"e_1_2_8_157_1","doi-asserted-by":"publisher","DOI":"10.1210\/js.2019-00004"},{"key":"e_1_2_8_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2020.129811"},{"key":"e_1_2_8_159_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b01862"},{"key":"e_1_2_8_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2021.04.015"},{"key":"e_1_2_8_161_1","doi-asserted-by":"publisher","DOI":"10.1054\/ijoa.2002.0970"},{"key":"e_1_2_8_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anclin.2017.01.007"},{"key":"e_1_2_8_163_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2009.01964.x"},{"key":"e_1_2_8_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.07.037"},{"key":"e_1_2_8_165_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.130.5.1315251"},{"key":"e_1_2_8_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.01.021"},{"key":"e_1_2_8_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010021\u201001141\u2010x"},{"key":"e_1_2_8_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2013.02.007"},{"key":"e_1_2_8_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.08.025"},{"key":"e_1_2_8_170_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsq085"},{"key":"e_1_2_8_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.05.003"},{"key":"e_1_2_8_172_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.339.6117.267"},{"key":"e_1_2_8_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.12.022"},{"key":"e_1_2_8_174_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221910859"},{"key":"e_1_2_8_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.10.020"}],"container-title":["Journal of Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.13106","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jne.13106","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.13106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T18:56:51Z","timestamp":1692644211000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jne.13106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,22]]},"references-count":174,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/jne.13106"],"URL":"https:\/\/doi.org\/10.1111\/jne.13106","archive":["Portico"],"relation":{},"ISSN":["0953-8194","1365-2826"],"issn-type":[{"value":"0953-8194","type":"print"},{"value":"1365-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,22]]},"assertion":[{"value":"2022-01-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13106"}}