{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:44:58Z","timestamp":1788371098438,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Complete surgical resection is the only hope to cure small intestine neuroendocrine neoplasms (SiNENs). However, inadequate lymphadenectomy or entire small bowel palpation for multiple primary tumours renders at least 20% of resections suboptimal. This study was undertaken to investigate reintervention outcomes after initial suboptimal resections (ISORs), and agreement between residual tumour identification on interval imaging and during reintervention. This retrospective, multicentre study included all patients undergoing reintervention within 18\u2009months post ISOR. Disease\u2010free survival (DFS) was defined as the time from reintervention resection date to recurrence or any\u2010cause of death. The kappa coefficient assessed agreement rates between suspected residual tumour on interval imaging and its presence at reintervention. A total of 21 patients underwent reintervention for nonmetastatic SiNENs (median follow\u2010up 2.3 [IQR 0.6\u20133.75] years). Residual tumour, suspected in 17\/21 (81%) patients based on interval imaging, was found in 20\/21 (95%) during reintervention. Interval imaging\u2013intraoperative detection agreement was fair for residual primary tumours (kappa\u00a0=\u00a00.28, 95% CI: 0.05\u20130.62;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.09) and residual lymph node metastases (kappa\u00a0=\u00a00.17, 95% CI: 0.28\u20130.62;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.45). Reintervention achieved complete tumour clearance in 16\/21 (76%) patients, among whom 5\/16 (31%) developed liver metastases during follow\u2010up. Median DFS was 70.6\u00a0months (IQR 39.7\u2013not reached). Reintervention post\u2010ISOR can obtain tumour clearance and prolonged remission. It should be systematically discussed after suspected ISOR, even when postoperative imaging does not find any residual tumour. To maximize detection of potentially resectable residual disease, imaging modalities after \u201ccurative\u201d surgery should be redefined.\n                  <\/jats:p>","DOI":"10.1111\/jne.13117","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T05:20:31Z","timestamp":1647235231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Concept of reintervention with thorough lymphadenectomy after suboptimal resection of\n                    <scp>small\u2010intestine<\/scp>\n                    neuroendocrine neoplasms: A multicentre preliminary study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8546-0433","authenticated-orcid":false,"given":"Sophie","family":"Deguelte","sequence":"first","affiliation":[{"name":"Department of Endocrine, Digestive and Oncological Surgery Robert\u2010Debr\u00e9 University Hospital  Reims France"},{"name":"Faculty of Medicine, UR 3797 Ageing, Frailty (VieFra) University of Reims Champagne\u2010Ardenne  Reims France"},{"name":"Reims Medical School University of Champagne Ardennes  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryne","family":"Hammoutene","sequence":"additional","affiliation":[{"name":"Department of Endocrine, Digestive and Oncological Surgery Robert\u2010Debr\u00e9 University Hospital  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Poncet","sequence":"additional","affiliation":[{"name":"Digestive and Oncologic Surgery, Edouard\u2010Herriot University Hospital Claude\u2010Bernard Lyon 1 University  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Brunaud","sequence":"additional","affiliation":[{"name":"Department of Digestive, Hepato\u2010Biliary and Endocrine Surgery University Hospital Nancy Brabois  Vandoeuvre\u2010les\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4528-5471","authenticated-orcid":false,"given":"Marine","family":"Perrier","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Gastro\u2010Enterology Robert\u2010Debr\u00e9 University Hospital  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Kianmanesh","sequence":"additional","affiliation":[{"name":"Department of Endocrine, Digestive and Oncological Surgery Robert\u2010Debr\u00e9 University Hospital  Reims France"},{"name":"Reims Medical School University of Champagne Ardennes  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Cadiot","sequence":"additional","affiliation":[{"name":"Reims Medical School University of Champagne Ardennes  Reims France"},{"name":"Department of Hepato\u2010Gastro\u2010Enterology Robert\u2010Debr\u00e9 University Hospital  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt377"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.0589"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6676-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.10.1502"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-017-3524-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2015.06.019"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-011-1296-z"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-013-1918-8"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-017-3645-1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000464292"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443170"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000846"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2020.02.011"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5574-8"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-020-05710-z"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481808401006"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2016.05.023"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2011.04.021"},{"key":"e_1_2_9_20_1","unstructured":"TNCD\u2010chapitre\u2010125\u20101.Date de cette version 12\/05\/2011. Disponible surWWW.tncd.org."},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000441423"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010232"},{"key":"e_1_2_9_23_1","unstructured":"Publication of WHO Classification of Tumours 5th Edition Volume 1: Digestive System Tumours \u2013 IARC https:\/\/www.iarc.who.int\/fr\/news-events\/publication-of-who-classification-of-tumours-5th-edition-volume-1-digestive-system-tumours\/(accessed 4 June 2021)."},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b13ca2"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2012.031"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.3326"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2020.09.015"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1677\/erc.0.0100469"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2015.0011"}],"container-title":["Journal of Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.13117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jne.13117","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.13117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:35:17Z","timestamp":1692750917000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jne.13117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,18]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/jne.13117"],"URL":"https:\/\/doi.org\/10.1111\/jne.13117","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JNE.13117\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13117\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13117\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13117\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13117\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13117\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13117\/v2\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13117\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13117\/v1\/review3","asserted-by":"object"}]},"ISSN":["0953-8194","1365-2826"],"issn-type":[{"value":"0953-8194","type":"print"},{"value":"1365-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,18]]},"assertion":[{"value":"2021-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13117"}}