{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:43:48Z","timestamp":1777376628429,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T00:00:00Z","timestamp":1654300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The incidence and prevalence of neuroendocrine neoplasms (NENs) has increased in the US in recent decades. These are well\u2010vascularized tumors, but no antiangiogenic drug has been approved for treatment of extra\u2010pancreatic NENs. The aim is to assess efficacy and safety of surufatinib in pancreatic and extra\u2010pancreatic NETs. We searched PubMed, Embase, Cochrane Library, Web of Science and <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link>. Clinical trials and observational studies that provided safety and efficacy data in clinical terms were included. Characteristics of the study, baseline characteristics of participants, treatment drugs, measures of efficacy, and toxicity (\u2265grade 3 adverse effects) were extracted. The meta\u2010analysis was performed using the \u201cR\u201d programming language. Risk ratio (RR) of objective response (OR)\/partial response (PR) was 8.55 (95% CI: 1.68\u201343.66, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u20090) in favor of surufatinib. The hazard ratio (HR) of progression\u2010free survival (PFS) was 0.48 (95% CI:\u00a00.25\u20130.92, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u200977%) in favor of surufatinib. The risk of \u2265grade 3 adverse effects: diarrhea, hypertension, hypertriglyceridemia, proteinuria, and vomiting were high with the use of surufatinib. Quality of life (QoL) was similar in surufatinib and placebo groups except for the diarrhea that was high with surufatinib. Lack of randomized clinical trials in non\u2010Chinese population. Surufatinib is well tolerated and is more effective than placebo in both pancreatic and extra\u2010pancreatic NETs. More multicenter randomized, double\u2010blinded clinical trials are needed to confirm these results.<\/jats:p>","DOI":"10.1111\/jne.13149","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T02:14:13Z","timestamp":1651025653000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy and toxicity of surufatinib in neuroendocrine tumors: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5586-6280","authenticated-orcid":false,"given":"Muhammad Ashar","family":"Ali","sequence":"first","affiliation":[{"name":"Beth Israel Deconess Medical Center Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed S.","family":"Shah","sequence":"additional","affiliation":[{"name":"University of Kentucky  Lexington Kentucky 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