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Almost half of these APTs and carcinomas are corticotroph tumors, suggesting a specific prognosis. Clinical, pathological and molecular prognostic markers are limited and do not allow early management of these tumors. Temozolomide remains the first\u2010line treatment once a diagnosis of aggressive pituitary tumor or carcinoma has been made. Novel alternative treatments exist, including immune checkpoint inhibitors, which can be used in the case of temozolomide treatment failure. The aim of this review is to present the clinical, pathological and molecular characteristics of aggressive corticotroph tumors and carcinomas, and to describe the results obtained with currently available treatments.<\/jats:p>","DOI":"10.1111\/jne.13169","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T04:57:59Z","timestamp":1653627479000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Aggressive corticotroph tumors and carcinomas"],"prefix":"10.1111","volume":"34","author":[{"given":"H\u00e9l\u00e8ne","family":"Lasolle","sequence":"first","affiliation":[{"name":"Inserm U1052, CNRS UMR5286 Cancer Research Center of Lyon  Lyon France"},{"name":"Lyon 1 University  Villeurbanne France"},{"name":"Endocrinology Department, Reference Center for Rare Pituitary Diseases HYPO \u201cGroupement Hospitalier Est\u201d Hospices Civils de Lyon  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Vasiljevic","sequence":"additional","affiliation":[{"name":"Inserm U1052, CNRS UMR5286 Cancer Research Center of Lyon  Lyon France"},{"name":"Lyon 1 University  Villeurbanne France"},{"name":"Pathology Department, Reference Center for Rare Pituitary Diseases HYPO \u201cGroupement Hospitalier Est\u201d Hospices Civils de Lyon  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Jouanneau","sequence":"additional","affiliation":[{"name":"Inserm U1052, CNRS UMR5286 Cancer Research Center of Lyon  Lyon France"},{"name":"Lyon 1 University  Villeurbanne France"},{"name":"Neurosurgery Department, Reference Center for Rare Pituitary Diseases HYPO \u201cGroupement Hospitalier Est\u201d Hospices Civils de Lyon  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirela Diana","family":"Ilie","sequence":"additional","affiliation":[{"name":"Inserm U1052, CNRS UMR5286 Cancer Research Center of Lyon  Lyon France"},{"name":"Lyon 1 University  Villeurbanne France"},{"name":"Endocrinology Department \u201cC.I. 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