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Previous work has shown that the ACBP\u2010derived octadecaneuropeptide exerts strong anorectic action via proopiomelanocortin (POMC) neuron activation and the melanocortin\u20104 receptor. Importantly, targeted ACBP loss\u2010of\u2010function in astrocytes promotes hyperphagia and diet\u2010induced obesity while its overexpression in arcuate astrocytes reduces feeding and body weight. Despite this knowledge, the role of astroglial ACBP in adaptive feeding and metabolic responses to acute metabolic challenges has not been investigated. Using different paradigms, we found that ACBP deletion in glial fibrillary acidic protein (GFAP)\u2010positive astrocytes does not affect weight loss when obese male mice are transitioned from a high fat diet to a chow diet, nor metabolic parameters in mice fed with a normal chow diet (e.g., energy expenditure, body temperature) during fasting, cold exposure and at thermoneutrality. In contrast, astroglial ACBP deletion impairs meal pattern and feeding responses during refeeding after a fast and during cold exposure, thereby showing that ACBP is required to stimulate feeding in states of increased energy demand. These findings challenge the general view that astroglial ACBP exerts anorectic effects and suggest that regulation of feeding by ACBP is dependent on metabolic status.<\/jats:p>","DOI":"10.1111\/jne.13218","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T04:20:20Z","timestamp":1668745220000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Role of astroglial\n                    <scp>ACBP<\/scp>\n                    in energy metabolism flexibility and feeding responses to metabolic challenges in male mice"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0542-0576","authenticated-orcid":false,"given":"Khalil","family":"Bouyakdan","sequence":"first","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM), Montreal Diabetes Research Center, and Departments of Medicine and Neurosciences 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