{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:01:58Z","timestamp":1790787718784,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Neuroendocrine tumors (NETs) are highly vascularized neoplasms. While FOLFOX chemotherapy has shown efficacy in patients with advanced NETs, its combination with antiangiogenics has been scarcely described. Here, we report the efficacy and tolerance of FOLFOX\u2010bevacizumab in this setting. We retrospectively studied all consecutive patients with metastatic NET treated by FOLFOX\u2010bevacizumab in two expert centers from 2013 to 2020. We assessed time to treatment failure (TTF), objective response rate (ORR) and toxicity. We explored factors associated with TTF and ORR using multivariate analyses. We included 57 patients (35.1% female, median age 61.7\u2009years), with pancreatic (66.7%), small\u2010intestine (14%) or lung (7%) NETs. Most patients (57.9%) had extra\u2010hepatic metastases and G3 NETs accounted for 40.3% of cases. Patients received a median of 17\u2009cycles of treatment, including a median of seven\u00a0cycles of bevacizumab and\/or 5\u2010fluorouracile maintenance. Median TTF was 15.5\u00a0months (95% CI: 9.8\u201321.2) and was shorter in patients age\u2009&gt;\u200960\u2009years (HR 2.56, 95% CI: 1.16\u20135.64),\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.020) and\u2009&gt;1 previous systemic treatment line (HR 4.15, 95% CI: 1.96\u20138.78),\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u2009.001). The ORR was 42.9% and was higher in cases of performance status at 0 (OR 5.25, 95% CI: 1.13\u201324.35),\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.034) and G3 NET (OR 5.39, 95% CI: 1.23\u201323.52),\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.025). The FOLFOX\u2010bevacizumab combination has promising efficacy in patients with progressive metastatic NETs and notably for G3 NETs, for which optimal treatment as yet remains ill\u2010defined. Hence, it could be a relevant alternative to alkylating\u2010based chemotherapy in this setting and should be further explored prospectively.\n                  <\/jats:p>","DOI":"10.1111\/jne.13227","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T07:28:23Z","timestamp":1672126103000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["<scp>FOLFOX<\/scp>\n                    \u2010bevacizumab chemotherapy in patients with metastatic neuroendocrine tumors"],"prefix":"10.1111","volume":"35","author":[{"given":"Caroline","family":"Lacombe","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris\u2010Cit\u00e9 Department of Pancreatology and Digestive Oncology, Beaujon Hospital (APHP.Nord)  Clichy France"},{"name":"Universit\u00e9 Paris\u2010Cit\u00e9 Center of Research on Inflammation, INSERM U1149  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4528-5471","authenticated-orcid":false,"given":"Marine","family":"Perrier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Reims\u2010Champagne\u2010Ardenne Department of Hepato\u2010Gastroenterology and Digestive Oncology, Robert\u2010Debr\u00e9 Hospital  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Hentic","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Cit\u00e9 Department of Pancreatology and Digestive Oncology, Beaujon Hospital (APHP.Nord)  Clichy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedia","family":"Brixi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Reims\u2010Champagne\u2010Ardenne Department of Hepato\u2010Gastroenterology and Digestive Oncology, Robert\u2010Debr\u00e9 Hospital  Reims 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Hospital (APHP.Nord)  Clichy France"},{"name":"Universit\u00e9 Paris\u2010Cit\u00e9 Center of Research on Inflammation, INSERM U1149  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Cadiot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Reims\u2010Champagne\u2010Ardenne Department of Hepato\u2010Gastroenterology and Digestive Oncology, Robert\u2010Debr\u00e9 Hospital  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Ruszniewski","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Cit\u00e9 Department of Pancreatology and Digestive Oncology, Beaujon Hospital (APHP.Nord)  Clichy France"},{"name":"Universit\u00e9 Paris\u2010Cit\u00e9 Center of Research on Inflammation, INSERM U1149  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9715-9189","authenticated-orcid":false,"given":"Louis","family":"de Mestier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Cit\u00e9 Department of Pancreatology and Digestive Oncology, Beaujon Hospital (APHP.Nord)  Clichy France"},{"name":"Universit\u00e9 Paris\u2010Cit\u00e9 Center of Research on Inflammation, INSERM U1149  Paris 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