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The hippocampal alterations associate with cognitive impairment. We have shown that hippocampal abnormalities are reversed by 17\u03b2\u2010estradiol, a steroid binding to intracellular receptors (estrogen receptor \u03b1 and \u03b2 subtypes) or the membrane\u2010located G\u2010protein coupled estradiol receptor. Genistein (GEN) is a neuroprotective phytoestrogen which binds to estrogen receptor \u03b2 and G\u2010protein coupled estradiol receptor. Here, we investigated whether GEN neuroprotection extends to SHR. For this purpose, we treated 5\u2010month\u2010old SHR for 2\u2009weeks with 10\u00a0mg\u2009kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    daily s.c injections of GEN. We analyzed the expression of doublecortin+ neuronal progenitors, glial fibrillary acidic protein+ astrocytes and ionized calcium\u2010binding adapter molecule 1+ microglia in the CA1 region and dentate gyrus of the hippocampus using immunocytochemistry, whereas a quantitative real\u2010time polymerase chain reaction was used to measure the expression of pro\u2010 and anti\u2010inflammatory factors tumor necrosis factor \u03b1, cyclooxygenase\u20102 and transforming growth factor \u03b2. We also evaluated hippocampal dependent memory using the novel object recognition test. The results showed a decreased number of doublecortin+ neural progenitors in the dentate gyrus of SHR that was reversed with GEN. The number of glial fibrillary acidic protein+ astrocytes in the dentate gyrus and CA1 was increased in SHR but significantly decreased by GEN treatment. Additionally, GEN shifted microglial morphology from the predominantly activated phenotype present in SHR, to the more surveillance phenotype found in normotensive rats. Furthermore, treatment with GEN decreased the mRNA of the pro\u2010inflammatory factors tumor necrosis factor \u03b1 and cyclooxygenase\u20102 and increased the mRNA of the anti\u2010inflammatory factor transforming growth factor \u03b2. Discrimination index in the novel object recognition test was decreased in SHR and treatment with GEN increased this parameter. Our results indicate important neuroprotective effects of GEN at the neurochemical and behavioral level in SHR. Our data open an interesting possibility for proposing this phytoestrogen as an alternative therapy in hypertensive encephalopathy.\n                  <\/jats:p>","DOI":"10.1111\/jne.13228","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T04:53:41Z","timestamp":1672808021000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Beneficial effects of\n                    <scp>the phytoestrogen<\/scp>\n                    genistein on hippocampal\n                    <scp>impairments<\/scp>\n                    of spontaneously hypertensive rats (\n                    <scp>SHR<\/scp>\n                    )"],"prefix":"10.1111","volume":"35","author":[{"given":"Santiago","family":"Ronchetti","sequence":"first","affiliation":[{"name":"Laboratory of Neuroendocrine Biochemistry Instituto de Biolog\u00eda y Medicina Experimental  Buenos Aires 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