{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:51:52Z","timestamp":1772160712512,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Pancreatic metastases (PMs) from neuroendocrine neoplasms (NENs) are rare but the increased sensitivity of new diagnostic tools such as\n                    <jats:sup>68<\/jats:sup>\n                    Ga\u2010DOTATATE PET\/CT has resulted in their increased recognition at initial diagnosis or follow\u2010up. A retrospective analysis of the data of patients from six tertiary referral centres was performed in order to identify the characteristics and the prognostic significance of PMs in patients with NENs. We used a control group of 69 age\u2010, sex\u2010 and primary tumour \u2013 matched NEN patients from the same cohort with stage IV disease but no PMs. Overall survival (OS) was assessed using the Kaplan\u2013Meier method log\u2010rank analysis was used to assess the impact of various clinical and histopathological variables in OS. We identified 25 patients (11 females) with PMs with a median age at diagnosis of 60\u2009years. The small intestine was the most common primary (80%) with a prevalence of 4.2% PMs (21\/506). Fourteen patients presented with synchronous PMs whereas 11 developed metachronous PMs after a median time of 28\u2009months (range: 7\u2013168\u2009months). Grading was available in 24 patients; 16 patients had G1 tumours, four G2, two atypical lung carcinoid, one typical and one atypical thymic carcinoid. Most patients had other concomitant metastases (12 hepatic, 4 lung and 6 bone) while five patients exhibited peritoneal carcinomatosis. Median OS in the PMs group was not reached compared with 212\u2009months in the control group (95% CI: 26\u2013398). The univariate analysis identified no prognostic factors statistically significantly associated with the OS. In conclusion, PMs are encountered with a low prevalence among NEN patients mostly developing in patients with advanced metastatic disease. The presence of PMs does not seem to be associated with a negative prognostic impact in OS.\n                  <\/jats:p>","DOI":"10.1111\/jne.13269","type":"journal-article","created":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T12:15:40Z","timestamp":1679832940000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pancreatic metastases in patients with neuroendocrine neoplasms: A\n                    <scp>multi\u2010centre<\/scp>\n                    cohort study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6013-5893","authenticated-orcid":false,"given":"Marina","family":"Tsoli","sequence":"first","affiliation":[{"name":"Neuroendocrine Tumour Unit, ENETS Centre of Excellence, First Department of Propaedeutic and Internal Medicine, Laiko Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4224-8912","authenticated-orcid":false,"given":"Kosmas","family":"Daskalakis","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"},{"name":"Second Department of Surgery, \"Korgialenio\u2010Benakio\" Red Cross General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Wedin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0906-3617","authenticated-orcid":false,"given":"Anna","family":"Angelousi","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, First Department of Internal Medicine, Laiko Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Povlsen","sequence":"additional","affiliation":[{"name":"Neuroendocrine Tumour Unit, ENETS Centre of Excellence King's College Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj","family":"Srirajaskanthan","sequence":"additional","affiliation":[{"name":"Neuroendocrine Tumour Unit, ENETS Centre of Excellence King's College Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Giovos","sequence":"additional","affiliation":[{"name":"The ARDEN NET Centre, ENETS Centre of Excellence University Hospitals Coventry and Warwickshire NHS Trust  Coventry UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4070-8164","authenticated-orcid":false,"given":"Martin O.","family":"Weickert","sequence":"additional","affiliation":[{"name":"The ARDEN NET Centre, ENETS Centre of Excellence University Hospitals Coventry and Warwickshire NHS Trust  Coventry UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelika","family":"Kogut","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Neuroendocrine Tumours, Department of Pathophysiology and Endocrinology Medical University of Silesia  Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3755-1722","authenticated-orcid":false,"given":"Beata","family":"Kos\u2010Kudla","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Neuroendocrine Tumours, Department of Pathophysiology and Endocrinology Medical University of Silesia  Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kira","family":"Oleinikov","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, ENETS Centre of Excellence, Department of Endocrinology and Metabolism, Hadassah Medical Centre and Faculty of Medicine The Hebrew University  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-9154","authenticated-orcid":false,"given":"Simona","family":"Grozinsky\u2010Glasberg","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, ENETS Centre of Excellence, Department of Endocrinology and Metabolism, Hadassah Medical Centre and Faculty of Medicine The Hebrew University  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Kaltsas","sequence":"additional","affiliation":[{"name":"Neuroendocrine Tumour Unit, ENETS Centre of Excellence, First Department of Propaedeutic and Internal Medicine, Laiko Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.4377"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443167"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.0589"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000287277"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428\u2010004\u20100987\u20103"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3181bae9b3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000352006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000979"},{"issue":"2","key":"e_1_2_8_10_1","first-page":"38","article-title":"Rectal neuroendocrine tumor with synchronous pancreatic metastasis: a case 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