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Guided by key clinical questions practical advice on the diagnosis and management of neuroendocrine tumours (NET) of the caecum, colon, and rectum is provided. Although covered in one guidance paper colorectal NET comprises a heterogeneous group of neoplasms. The most common rectal NET are often small G1 tumours that can be treated by adequate endoscopic resection techniques. Evidence from prospective clinical trials on the treatment of metastatic colorectal NET is limited and discussion of patients in experienced multidisciplinary tumour boards strongly recommended. Neuroendocrine carcinomas (NEC) and mixed neuroendocrine non\u2010neuroendocrine neoplasms (MiNEN) are discussed in a separate guidance paper.<\/jats:p>","DOI":"10.1111\/jne.13309","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T10:56:05Z","timestamp":1685703365000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":175,"title":["European Neuroendocrine Tumor Society (\n                    <scp>ENETS<\/scp>\n                    ) 2023 guidance paper for colorectal neuroendocrine tumours"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8156-2915","authenticated-orcid":false,"given":"Anja","family":"Rinke","sequence":"first","affiliation":[{"name":"Department of Gastroenterology University Hospital Marburg and Philipps University Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Ambrosini","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Alma Mater Studiorum University of Bologna  Bologna Italy"},{"name":"IRCSS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2999-1958","authenticated-orcid":false,"given":"Clarisse","family":"Dromain","sequence":"additional","affiliation":[{"name":"Department of Radiology CHUV Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocio","family":"Garcia\u2010Carbonero","sequence":"additional","affiliation":[{"name":"Department of Oncology Hospital Universitario 12 de Octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amyn","family":"Haji","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4159-2511","authenticated-orcid":false,"given":"Anna","family":"Koumarianou","sequence":"additional","affiliation":[{"name":"Hematology Oncology Unit, Fourth Department of Internal Medicine Attikon University Hospital, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Els Nieveen","family":"van Dijkum","sequence":"additional","affiliation":[{"name":"Department of Surgery, Amsterdam UMC, Amsterdam, Cancer Center Amsterdam University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dermot","family":"O'Toole","sequence":"additional","affiliation":[{"name":"NET Center of Excellence St Vincent's University Hospital and St James Hospital Dublin 8 and Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2996-4404","authenticated-orcid":false,"given":"Guido","family":"Rindi","sequence":"additional","affiliation":[{"name":"Section of Anatomic Pathology, Department of Life Sciences and Public Health, Universit\u00e0 Cattolica del Sacro Cuore; Unit of Head and Neck, Thoracic and Endcorine Pathology, Department of Woman and Child Health and Public Health Fondazione Policlinico Universitario A. 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