{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:39:24Z","timestamp":1788871164437,"version":"build-2803163510"},"reference-count":106,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T00:00:00Z","timestamp":1690588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16H06280"],"award-info":[{"award-number":["16H06280"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K06722"],"award-info":[{"award-number":["20K06722"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K15837"],"award-info":[{"award-number":["20K15837"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H02656"],"award-info":[{"award-number":["22H02656"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K19332"],"award-info":[{"award-number":["22K19332"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007434","name":"Suzuken Memorial Foundation","doi-asserted-by":"publisher","award":["19\u2010085"],"award-info":[{"award-number":["19\u2010085"]}],"id":[{"id":"10.13039\/100007434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011746","name":"NOVARTIS Foundation (Japan) for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011746","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The neuropeptidergic mechanisms controlling socio\u2010sexual behaviours consist of complex neuronal circuitry systems in widely distributed areas of the brain and spinal cord. At the organismal level, it is now becoming clear that \u201chormonal regulations\u201d play an important role, in addition to the activation of neuronal circuits. The gastrin\u2010releasing peptide (GRP) system in the lumbosacral spinal cord is an important component of the neural circuits that control penile reflexes in rats, circuits that are commonly referred to as the \u201cspinal ejaculation generator (SEG).\u201d Oxytocin, long known as a neurohypophyseal hormone, is now known to be involved in the regulation of socio\u2010sexual behaviors in mammals, ranging from social bonding to empathy. However, the functional interaction between the SEG neurons and the hypothalamo\u2010spinal oxytocin system remains unclear. Oxytocin is known to be synthesised mainly in hypothalamic neurons and released from the posterior pituitary into the circulation. Oxytocin is also released from the dendrites of the neurons into the hypothalamus where they have important roles in social behaviours via non\u2010synaptic volume transmission. Because the most familiar functions of oxytocin are to regulate female reproductive functions including parturition, milk ejection, and maternal behaviour, oxytocin is often thought of as a \u201cfeminine\u201d hormone. However, there is evidence that a group of parvocellular oxytocin neurons project to the lower spinal cord and control male sexual function in rats. In this report, we review the functional interaction between the SEG neurons and the hypothalamo\u2010spinal oxytocin system and effects of these neuropeptides on male sexual behaviour. Furthermore, we discuss the finding of a recently identified, localised \u201cvolume transmission\u201d role of oxytocin in the spinal cord. Findings from our studies suggest that the newly discovered \u201coxytocin\u2010mediated spinal control of male sexual function\u201d may be useful in the treatment of erectile and ejaculatory dysfunction.<\/jats:p>","DOI":"10.1111\/jne.13324","type":"journal-article","created":{"date-parts":[[2023,7,16]],"date-time":"2023-07-16T06:54:31Z","timestamp":1689490471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Neuropeptidergic control circuits in the spinal cord for male sexual behaviour: Oxytocin\u2013gastrin\u2010releasing peptide systems"],"prefix":"10.1111","volume":"35","author":[{"given":"Takumi","family":"Oti","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science Kanagawa University  Hiratsuka Japan"},{"name":"Ushimado Marine Institute (UMI), Faculty of Environmental, Life, Natural Science and Technology Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6224-4591","authenticated-orcid":false,"given":"Hirotaka","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Ushimado Marine Institute (UMI), Faculty of Environmental, Life, Natural Science and Technology Okayama University  Okayama Japan"},{"name":"Department of Biology, Faculty of Environmental, Life, Natural Science and Technology Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,29]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)64441-6"},{"key":"e_1_2_15_3_1","volume-title":"Behavioral neuroscience","author":"Breedlove SM","year":"2020"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0559"},{"issue":"1","key":"e_1_2_15_5_1","first-page":"R180","article-title":"Hindbrain GRP receptor blockade antagonizes feeding suppression by peripherally administered GRP","volume":"271","author":"Ladenheim EE","year":"1996","journal-title":"Am J Physiol"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890008998831"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04633.x"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90585-1"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-02-00793.1993"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1219-06.2006"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816X.2004.03175.x"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01116-9"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(91)90005-F"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2126"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2012.02688.x"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.2741\/3970"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1325"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-102320-102847"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221910376"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/19420889.2021.1902056"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.09.089"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02145873"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(79)91614-0"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(83)90814-8"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-820649-2.00086-3"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-92528-x"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)50516-6"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34135"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101366"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23506"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X12666140923201432"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90250-4"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)53415-3"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.10.068"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/1044-7431(92)90056-8"},{"issue":"289","key":"e_1_2_15_36_1","article-title":"Footedness for scratching itchy eyes in rodents","volume":"2022","author":"Katayama Y","year":"1985","journal-title":"Proc Biol Sci"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06029"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23154"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1990.tb08830.x"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1073885"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90312-U"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00819-8"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00446-2"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(87)90103-5"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-01-00325.2003"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004276"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-1791"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7423210"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.19.7527"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2007.11.008"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12418"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-012-0976-6"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00184"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2017.105"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.10.068"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24138"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24819"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2008.08.004"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.04.106"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-016-0058-x"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.92.69"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2013.10.006"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018-00043"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(89)90153-7"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(95)00025-S"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0485"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-005-0014-2"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2019.6509"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13515"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10739"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.10.008"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12565-010-0097-z"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10740"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(97)00190-3"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20784"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2011.11.002"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1158668"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1570343"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2017.08.005"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.01.062"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.01.034"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1845"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1327"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2012.147"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2005.06.002"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901880108"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91629-F"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903360109"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(97)00386-7"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.05.025"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.1997.00659.x"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.134.6.8194487"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24216"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91485-X"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(96)00800-1"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.176"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.10.014"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.111.004952"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2011.02574.x"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-02090-2"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2011.12.009"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2006.01.001"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02184.x"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(94)90313-1"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(97)00258-8"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S185757"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sxmr.2021.07.001"}],"container-title":["Journal of Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.13324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T22:28:09Z","timestamp":1695680889000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jne.13324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,29]]},"references-count":106,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/jne.13324"],"URL":"https:\/\/doi.org\/10.1111\/jne.13324","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JNE.13324\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13324\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13324\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13324\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13324\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13324\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13324\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13324\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0953-8194","1365-2826"],"issn-type":[{"value":"0953-8194","type":"print"},{"value":"1365-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,29]]},"assertion":[{"value":"2022-12-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13324"}}