{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:20:09Z","timestamp":1788967209658,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The outcome following surgery for patients with primary lung neuroendocrine tumors at metastatic stage remains poorly characterized. We conducted a retrospective national study including patients with metastatic lung neuroendocrine tumors at diagnosis. We performed a safety study to evaluate major morbidity and mortality of surgical resection of the primary tumor and compared patients in the operative to the nonoperative group. A total of 155 patients were included: 41 in the operative group and 114 in the nonoperative group, median age was 64\u2009years. Metastases were mainly located in the liver (74.2%) and the bone (49.7%). The primary endpoint was met as the rate of major complications was 4.9% and there was no postoperative mortality. In the operative group 42.5% of patients had improvement of their pulmonary symptoms versus 14.4% in the nonoperative group. The median overall survival was not reached in the operative group and was 4.3\u2009years (95% CI [3.5;4.9]) in the nonoperative group (univariate analysis, HR\u2009=\u20090.42 95% CI [0.23\u20130.77],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.002). After multivariate analysis, only an ECOG\u2010PS \u22651 (vs. 0, HR\u2009=\u20092.44, 95% CI [1.46;4.07],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.001) and &gt;1 metastatic site (vs. 1; HR\u2009=\u20091.83, 95% CI [1.06;3.16],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.030) remained significantly associated with overall survival. The resection of the primary tumor was not significantly associated with overall survival (HR\u2009=\u20090.63, 95% CI [0.32;1.24],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.183). In conclusion, surgery of primary lung neuroendocrine tumors at metastatic stage is a safe option that should be considered in selected patients in order to improve symptoms with a view to improving their quality of life. Larger studies are warranted to evaluate the impact of surgery on survival.\n                  <\/jats:p>","DOI":"10.1111\/jne.13331","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T01:25:40Z","timestamp":1691457940000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Surgery of primary lung carcinoid tumors at metastatic stage: A national study from the French Group of Endocrine Tumors (\n                    <scp>GTE<\/scp>\n                    ) and ENDOCAN\u2010RENATEN network"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0563-4868","authenticated-orcid":false,"given":"Lucie","family":"Duponchelle","sequence":"first","affiliation":[{"name":"Service de Chirurgie Thoracique Groupement Hospitalier Est, Hospices Civils de Lyon  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Baudin","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Nucl\u00e9aire et Canc\u00e9rologie Endocrinienne Institut Gustave Roussy  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Subtil","sequence":"additional","affiliation":[{"name":"Service de Biostatistiques, Hospices Civils de Lyon  Lyon France"},{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, CNRS, Laboratoire de Biom\u00e9trie et Biologie Evolutive UMR 5588  Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Do Cao","sequence":"additional","affiliation":[{"name":"Service d'Endocrinologie Centre Hospitalier Universitaire de Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Dansin","sequence":"additional","affiliation":[{"name":"Comit\u00e9 d'Oncologie Thoracique, CLCC Oscar Lambret  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4528-5471","authenticated-orcid":false,"given":"Marine","family":"Perrier","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9pato\u2010Gastro\u2010Ent\u00e9rologie Centre Hospitalier Universitaire de Reims et Champagne\u2010Ardenne  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Pierre","family":"Teissier","sequence":"additional","affiliation":[{"name":"Service d'Endocrinologie Diab\u00e8te et Maladies M\u00e9taboliques, Centre Hospitalier Universitaire de Limoges  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magalie","family":"Haissaguerre","sequence":"additional","affiliation":[{"name":"Service d'Endocrinologie et Oncologie Endocrinienne H\u00f4pital Haut Leveque, Centre Hospitalier Universitaire de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Cansouline","sequence":"additional","affiliation":[{"name":"INSERM N2C UMR 1069, Universit\u00e9 de Tours, Service de Chirurgie Thoracique, Centre Hospitalier Universitaire de Tours  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Hadoux","sequence":"additional","affiliation":[{"name":"Service de Canc\u00e9rologie Endocrinienne Institut Gustave Roussy  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina","family":"Jepiral","sequence":"additional","affiliation":[{"name":"Groupe d'\u00e9tude des Tumeurs Endocrines (GTE)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Lombard\u2010Bohas","sequence":"additional","affiliation":[{"name":"Oncologie M\u00e9dicale, Groupement Hospitalier Centre Institut de Canc\u00e9rologie des Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Mercier","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Thoracique et Transplantation Cardio\u2010Pulmonaire H\u00f4pital Marie Lannelongue, Universit\u00e9 Paris\u2010Saclay, Centre International des Cancers Thoraciques, GHPSJ  Le Plessis Robinson France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Tronc","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Thoracique Groupement Hospitalier Est, Hospices Civils de Lyon  Bron France"},{"name":"University of Lyon, Universit\u00e9 Lyon 1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Walter","sequence":"additional","affiliation":[{"name":"Oncologie M\u00e9dicale, Groupement Hospitalier Centre Institut de Canc\u00e9rologie des Hospices Civils de Lyon  Lyon France"},{"name":"University of Lyon, Universit\u00e9 Lyon 1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Thoracic Tumours","author":"International Agency for 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