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One of the main brain sites for angiotensin II (ANG II)\/type 1 receptor (AT\n                    <jats:sub>1<\/jats:sub>\n                    R) signalling is the subfornical organ (SFO), a circumventricular organ related to the control of autonomic functions, motivated behaviours and energy metabolism. Thus, we hypothesised that circulating ANG II may act on the SFO AT\n                    <jats:sub>1<\/jats:sub>\n                    R receptors to integrate metabolic and hydromineral balance. We evaluated whether food deprivation can modulate systemic RAS activity and\n                    <jats:italic>Agrt1a<\/jats:italic>\n                    brain expression, and if ANG II\/AT\n                    <jats:sub>1<\/jats:sub>\n                    R signalling influences the hypothalamic expression of mRNAs encoding neuropeptides and food and water ingestion in fed and fasted Wistar rats. We found a significant increase in both ANG I and ANG II plasma levels after 24 and 48\u2009h of fasting. Expression of\n                    <jats:italic>Agrt1a<\/jats:italic>\n                    mRNA in the SFO and paraventricular nucleus (PVN) also increased after food deprivation for 48\u2009h. Treatment of fasted rats with low doses of losartan in drinking water attenuated the decrease in glycemia and meal\u2010associated water intake without changing the expression in PVN or arcuate nucleus of mRNAs encoding selected neuropeptides related to energy homeostasis control. These findings point to a possible role of peripheral ANG II\/SFO\u2010AT\n                    <jats:sub>1<\/jats:sub>\n                    R signalling in the control of refeeding\u2010induced thirst. On the other hand, intracerebroventricular losartan treatment decreased food and water intake over dark time in fed but not in fasted rats.\n                  <\/jats:p>","DOI":"10.1111\/jne.13334","type":"journal-article","created":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T12:02:33Z","timestamp":1692187353000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Fasting increases circulating angiotensin levels and brain\n                    <scp>\n                      <i>Agtr1a<\/i>\n                    <\/scp>\n                    expression in male rats"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2976-6523","authenticated-orcid":false,"given":"Bruno","family":"Paes\u2010Leme","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences, Institute of Biological and Health Sciences Federal Rural University of Rio de Janeiro  Serop\u00e9dica Rio de 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