{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:51:56Z","timestamp":1772160716374,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","award":["FO2019\u20100086"],"award-info":[{"award-number":["FO2019\u20100086"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","award":["FO2023\u20100437"],"award-info":[{"award-number":["FO2023\u20100437"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013491","name":"Jane och Dan Olssons Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF0078215"],"award-info":[{"award-number":["NNF0078215"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF19OC0056694"],"award-info":[{"award-number":["NNF19OC0056694"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007464","name":"Torsten S\u00f6derbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007464","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2019\u201001164"],"award-info":[{"award-number":["2019\u201001164"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2023\u20102026"],"award-info":[{"award-number":["2023\u20102026"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We previously provided evidence supporting the existence of a novel leptin\u2010independent body weight homeostat (\u201cthe gravitostat\u201d) that senses body weight and then initiates a homeostatic feed\u2010back regulation of body weight. We, herein, hypothesize that this feed\u2010back regulation involves a CNS mechanism. To identify populations of neurones of importance for the putative feed\u2010back signal induced by increased loading, high\u2010fat diet\u2010fed rats or mice were implanted intraperitoneally or subcutaneously with capsules weighing \u223c15% (Load) or \u223c2.5% (Control) of body weight. At 3\u20135\u2009days after implantation, neuronal activation was assessed in different parts of the brain\/brainstem by immunohistochemical detection of FosB. Implantation of weighted capsules, both subcutaneous and intraperitoneal, induced FosB in specific neurones in the medial nucleus of the solitary tract (mNTS), known to integrate information about the metabolic status of the body. These neurones also expressed tyrosine hydroxylase (TH) and dopamine\u2010beta\u2010hydroxylase (DbH), a pattern typical of norepinephrine neurones. In functional studies, we specifically ablated norepinephrine neurones in mNTS, which attenuated the feed\u2010back regulation of increased load on body weight and food intake. In conclusion, increased load appears to reduce body weight and food intake via activation of norepinephrine neurones in the mNTS.<\/jats:p>","DOI":"10.1111\/jne.13352","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T01:35:28Z","timestamp":1698370528000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Reduction of body weight by increased loading is associated with activation of norepinephrine neurones in the medial nucleus of the solitary tract"],"prefix":"10.1111","volume":"35","author":[{"given":"Jovana","family":"Zlatkovic","sequence":"first","affiliation":[{"name":"Departement of Neuroscience and Physiology University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8410-8048","authenticated-orcid":false,"given":"Adri\u00e0","family":"Dalmau Gasull","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"H\u00e4gg","sequence":"additional","affiliation":[{"name":"Departement of Neuroscience and Physiology University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferran","family":"Font\u2010Giron\u00e8s","sequence":"additional","affiliation":[{"name":"Departement of Neuroscience and Physiology University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob","family":"Bellman","sequence":"additional","affiliation":[{"name":"Departement of Neuroscience and Physiology University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Meister","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilborg","family":"Palsdottir","sequence":"additional","affiliation":[{"name":"AstraZeneca  M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Ruud","sequence":"additional","affiliation":[{"name":"Departement of Neuroscience and Physiology University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claes","family":"Ohlsson","sequence":"additional","affiliation":[{"name":"Center for Bone and Arthritis Research University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne L.","family":"Dickson","sequence":"additional","affiliation":[{"name":"Departement of Neuroscience and Physiology University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8988-1163","authenticated-orcid":false,"given":"Fredrik","family":"Anesten","sequence":"additional","affiliation":[{"name":"Departement of Neuroscience and Physiology University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John\u2010Olov","family":"Jansson","sequence":"additional","affiliation":[{"name":"Departement of Neuroscience and Physiology University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,26]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"WHO.World Obesity Day 2022 \u2010 Accelerating action to stop obesity. 2022. Accessed November 24 2022.https:\/\/www.who.int\/news\/item\/04\u201003\u20102022\u2010world\u2010obesity\u2010day\u20102022\u2010accelerating\u2010action\u2010to\u2010stop\u2010obesity"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0176-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13435"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.645563"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206038"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/372425a0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/27376"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00429772"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408399309527632"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-019-0095-y"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.62.1.413"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.01.002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1715687114"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018-00307"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.06.015"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2006.08.018"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2009.10"},{"issue":"1","key":"e_1_2_9_19_1","first-page":"727","article-title":"Demonstration and mapping of central neurons containing dopamine, noradrenaline, and 5\u2010hydroxytryptamine and their reactions to psychopharmaca","volume":"18","author":"Hillarp NA","year":"1966","journal-title":"Pharmacol Rev"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902330303"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02147990"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.00011.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.11.016"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.182.4108.166"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2396(20010101)39:1<32::AID-SYN5>3.0.CO;2-3"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23152"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)00855-4"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1999.277.4.R1063"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-31-10084.2003"},{"key":"e_1_2_9_30_1","volume-title":"Paxinos and Franklin's the Mouse Brain in Stereotaxic Coordinates","author":"Paxinos G","year":"2012"},{"key":"e_1_2_9_31_1","first-page":"209","volume-title":"The Rat Brain in Stereotaxic Coordinates\u2014The New Coronal Set","author":"Paxinos G","year":"2004"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp184"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.4035354"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2008.01734.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018-01002"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.10.003"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.12225"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1006\/frne.1994.1012"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00434-4"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.07.084"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.12.036"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.04.006"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202001456RRR"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-24716-3_15"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.09.002"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/lifemeta\/loac002"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000629"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1367.017"}],"container-title":["Journal of Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jne.13352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T05:13:36Z","timestamp":1702962816000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jne.13352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,26]]},"references-count":48,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/jne.13352"],"URL":"https:\/\/doi.org\/10.1111\/jne.13352","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JNE.13352\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13352\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13352\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13352\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13352\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13352\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13352\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13352\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JNE.13352\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0953-8194","1365-2826"],"issn-type":[{"value":"0953-8194","type":"print"},{"value":"1365-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,26]]},"assertion":[{"value":"2023-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13352"}}