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Disruptions to GnRH secretion patterns may contribute to polycystic ovary syndrome (PCOS). Prenatally androgenized (PNA) female mice recapitulate many neuroendocrine abnormalities observed in PCOS patients. PNA and development induce changes in spontaneous GnRH neuron firing rate, response to synaptic input, and the afterhyperpolarization potential of the action potential. We hypothesized potassium currents are altered by PNA treatment and\/or development. Whole\u2010cell patch\u2010clamp recordings were made of transient and residual potassium currents of GnRH neurons in brain slices from 3\u2010week\u2010old and adult control and PNA females. At 3\u2009weeks of age, PNA treatment increased transient current density versus controls. Development and PNA altered voltage\u2010dependent activation and inactivation of the transient current. In controls, transient current activation and inactivation were depolarized at 3\u2009weeks of age versus in adulthood. In GnRH neurons from 3\u2010week\u2010old mice, transient current activation and inactivation were more depolarized in control than PNA mice. Development and PNA treatment interacted to shift the time\u2010dependence of inactivation and recovery from inactivation. Notably, in cells from adult PNA females, recovery was prolonged compared to all other groups. Activation of the residual current occurred at more depolarized membrane potentials in 3\u2010week\u2010old than adult controls. PNA depolarized activation of the residual current in adults. These findings demonstrate the properties of GnRH neuron potassium currents change during typical development, potentially contributing to puberty, and further suggest PNA treatment may both alter some typical developmental changes and induce additional modifications, which together may underlie aspects of the PNA phenotype. There was not any clinical trial involved in this work.<\/jats:p>","DOI":"10.1111\/jne.13373","type":"journal-article","created":{"date-parts":[[2024,2,25]],"date-time":"2024-02-25T23:44:32Z","timestamp":1708904672000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Development and prenatal exposure to androgens alter potassium currents in gonadotropin\u2010releasing hormone neurons from female mice"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0870-2149","authenticated-orcid":false,"given":"Jennifer","family":"Jaime","sequence":"first","affiliation":[{"name":"The Neuroscience Graduate Program University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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