{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:14:47Z","timestamp":1784733287236,"version":"3.55.0"},"reference-count":73,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Patients with neuroendocrine tumours located in the gastroenteropancreatic tract (GEP\u2010NETs) and treatment with somatostatin analogues (SSA's) are at risk of malnutrition which has been reported previously evaluating weight loss or body mass index (BMI) only. The global leadership into malnutrition (GLIM) criteria include weight loss, BMI, and sarcopenia, for diagnosing malnutrition. These GLIM criteria have not been assessed in patients with GEP\u2010NETs on SSA. The effect of malnutrition on overall survival has not been explored before. The aim of this study is to describe the presence of malnutrition in patients with GEP\u2010NET on SSA based on the GLIM criteria and associate this with overall survival. Cross\u2010sectional study screening all patients with GEP\u2010NETs on SSA's for malnutrition using the GLIM criteria. Body composition analysis for sarcopenia diagnosis were performed. Bloods including vitamins, minerals, and lipid profile were collected. Overall survival since the date of nutrition screening was calculated. Uni\u2010 and multivariate Cox regression analysis were performed to identify malnutrition as risk factor for overall survival. A total of 118 patients, 47% male, with median age 67\u2009years (IQR 56.8\u201375.0) were included. Overall, malnutrition was present in 88 patients (75%); based on low BMI in 26 (22%) patients, based on weight loss in 35 (30%) patients, and based on sarcopenia in 83 (70%) patients. Vitamin deficiencies were present for vitamin D in 64 patients (54%), and vitamin A in 29 patients (25%). The presence of malnutrition demonstrated a significantly worse overall survival (\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value\u2009=\u2009.01). In multivariate analysis meeting 2 or 3 GLIM criteria was significantly associated with worse overall survival (HR 2.16 95% CI 1.34\u20133.48,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value\u2009=\u2009.002). Weight loss was the most important risk factor out of the 3 GLIM criteria (HR 3.5 95% CI 1.14\u201310.85,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value\u2009=\u2009.03) for worse overall survival. A high percentage (75%) of patients with GEP\u2010NETs using a SSA meet the GLIM criteria for malnutrition. Meeting more than 1 GLIM criterium, especially if there is weight loss these are risk factors for worse overall survival.\n                  <\/jats:p>","DOI":"10.1111\/jne.13376","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:31:10Z","timestamp":1708648270000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The global leadership into malnutrition criteria reveals a high percentage of malnutrition which influences overall survival in patients with gastroenteropancreatic neuroendocrine tumours"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8116-962X","authenticated-orcid":false,"given":"Dominique S. V. M.","family":"Clement","sequence":"first","affiliation":[{"name":"Kings Health Partners, ENETS Centre of Excellence Institute of Liver Studies, King's College Hospital London  London UK"},{"name":"Department of Gastroenterology King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique E.","family":"van Leerdam","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology Netherlands Cancer Institute, ENETS Centre of Excellence  Amsterdam The Netherlands"},{"name":"Department of Gastroenterology and Hepatology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot E. 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