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Shortly after birth, gonadotropin\u2010releasing hormone (GnRH) neurons in the hypothalamus are activated, a phenomenon known as minipuberty. This phenomenon, observed in all mammals studied, influences the postnatal development of the hypothalamic\u2013pituitary\u2013gonadal (HPG) axis and reproductive function. This review will put into perspective the results of recent studies showing that the impact of minipuberty extends beyond reproductive function, influencing sensory and cognitive maturation. Studies in mice have revealed the role of nitric oxide (NO) in regulating minipuberty amplitude, with NO deficiency linked to cognitive and olfactory deficits. Additionally, findings indicate that cognitive and sensory defects in adulthood in a mouse model of Down syndrome are associated with an age\u2010dependent decline of GnRH production, whose origin can be traced back to minipuberty, and point to the potential therapeutic role of pulsatile GnRH administration in cognitive disorders. Furthermore, this review delves into the repercussions of COVID\u201019 on GnRH production, emphasizing potential consequences for neurodevelopment and cognitive function in infected individuals. Notably, GnRH neurons appear susceptible to SARS\u2010CoV\u20102 infection, raising concerns about potential long\u2010term effects on brain development and function. In conclusion, the intricate interplay between GnRH neurons, GnRH release, and the activity of various extrahypothalamic brain circuits reveals an unexpected role for these neuroendocrine neurons in the development and maintenance of sensory and cognitive functions, supplementing their established function in reproduction. Therapeutic interventions targeting the HPG axis, such as inhaled NO therapy in infancy and pulsatile GnRH administration in adults, emerge as promising approaches for addressing neurodevelopmental cognitive disorders and pathological aging.<\/jats:p>","DOI":"10.1111\/jne.13387","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T22:38:53Z","timestamp":1712097533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Novel insights into minipuberty and\n                    <scp>GnRH<\/scp>\n                    : Implications on neurodevelopment, cognition, and\n                    <scp>COVID<\/scp>\n                    \u201019 therapeutics"],"prefix":"10.1111","volume":"36","author":[{"given":"Konstantina","family":"Chachlaki","sequence":"first","affiliation":[{"name":"Univ. 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