{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:51:51Z","timestamp":1772160711874,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Neuroendocrinology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"Abstract<\/jats:title>\n \n Metastases outside the liver and abdominal\/retroperitoneal lymph nodes are nowadays detected frequently in patients with neuroendocrine tumours (NETs), owing to the high sensitivity of positron emission tomography (PET) with Gallium\u201068\u2010DOTA\u2010somatostatin analogues (\n 68<\/jats:sup>\n Ga\u2010SSA) and concomitant diagnostic computed tomography (CT). Our aim was to determine the prevalence of extra\u2010abdominal metastases on\n 68<\/jats:sup>\n Ga\u2010DOTATOC\u2010PET\/CT in a cohort of patients with small intestinal (Si\u2010NET) and pancreatic NET (Pan\u2010NET), as well as that of pancreatic metastasis in patients with Si\u2010NET. Among 2090 patients examined by\n 68<\/jats:sup>\n Ga\u2010DOTATOC\u2010PET\/CT at two tertiary referral centres, a total of 1177 patients with a history of Si\u2010 or Pan\u2010NET, were identified. The most recent\n 68<\/jats:sup>\n Ga\u2010DOTATOC\u2010PET\/CT report for each patient was reviewed, and the location and number of metastases of interest were recorded. Lesions outside the liver and abdominal nodes were found in 26% of patients (\n n<\/jats:italic>\n \u2009=\u2009310\/1177), of whom 21.5% (255\/1177) were diagnosed with Si\u2010NET and 4.5% (55\/1177) Pan\u2010NET. Bone metastases were found in 18.4% (215\/1177), metastases to Virchow's lymph node in 7.1% (83\/1177), and lung\/pleura in 4.8% (56\/1177). In the subset of 255 Si\u2010NET patients, 5.4% (41\/255) manifested lesions in the pancreas, 1.5% in the breast (18\/255), 1.3% in the heart (15\/255) and 1% in the orbita (12\/255). In Si\u2010NET patients, the Ki\u201067 proliferation index was higher in those with \u22652 metastatic sites of interest, than with 1 metastatic site, (\n p<\/jats:italic>\n <0.001). Overall, extra\u2010abdominal or pancreatic metastases were more often found in patients with Si\u2010NET (34%) than in those with Pan\u2010NET (13%) (\n p<\/jats:italic>\n <0.001). Bone metastases were 2.6 times more frequent in patients with Si\u2010NET compared to Pan\u2010NET patients (\n p<\/jats:italic>\n <0.001). Lesions to the breast and orbita were encountered in almost only Si\u2010NET patients. In conclusion, lesions outside the liver and abdominal nodes were detected in as many as 26% of the patients, with different prevalence and metastatic patterns in patients with Si\u2010NET compared to Pan\u2010NET. The impact of such metastases on overall survival and clinical decision\u2010making needs further evaluation.\n <\/jats:p>","DOI":"10.1111\/jne.13391","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T03:35:23Z","timestamp":1712633723000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prevalence of metastases outside the liver and abdominal lymph nodes on\n \n 68<\/sup>\n Ga\u2010DOTATOC\u2010PET\n <\/scp>\n \/\n CT<\/scp>\n in patients with small intestinal and pancreatic neuroendocrine tumours"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4391-9650","authenticated-orcid":false,"given":"Maria","family":"Wedin","sequence":"first","affiliation":[{"name":"Department of Surgery, Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva Tiensuu","family":"Janson","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Endocrine Oncology unit Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"Wallin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2214-6217","authenticated-orcid":false,"given":"Anders","family":"Sundin","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Radiology and Molecular Imaging Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosmas","family":"Daskalakis","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine and Health \u00d6rebro University \u00d6rebro Sweden"},{"name":"2nd Department of Surgery, \u2018Korgialenio\u2010Benakio\u2019 Red Cross General Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.0589"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-020-0525-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000457954"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v5.i8.177"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0000000000001064"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-013-2037-2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14040913"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13269"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000471879"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000267"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-14-0119"},{"issue":"2","key":"e_1_2_9_13_1","first-page":"184","article-title":"Bone metastases in carcinoid tumors: clinical features, imaging characteristics, and markers of bone metabolism","volume":"44","author":"Meijer WG","year":"2003","journal-title":"J Nucl Med"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-02130-5"},{"issue":"6","key":"e_1_2_9_15_1","first-page":"1084","article-title":"Uveal metastasis from carcinoid tumor. 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